Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit

Throughout evolution, the need for single-celled organisms to associate and form a single cluster of cells has had several evolutionary advantages. In complex, multicellular organisms, each tissue or organ has a specialty and function that make life together possible, and the organism as a whole nee...

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Autores principales:	Pedro H. S. Pereira, Celia R. S. Garcia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Plasmodium falciparum</i> cell signaling GPCRs synchronization calcium Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f24a84b2e4da44afa9a858122e0f2005
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spelling	oai:doaj.org-article:f24a84b2e4da44afa9a858122e0f20052021-11-25T17:56:02ZEvidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit10.3390/ijms2222123811422-00671661-6596https://doaj.org/article/f24a84b2e4da44afa9a858122e0f20052021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12381https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Throughout evolution, the need for single-celled organisms to associate and form a single cluster of cells has had several evolutionary advantages. In complex, multicellular organisms, each tissue or organ has a specialty and function that make life together possible, and the organism as a whole needs to act in balance and adapt to changes in the environment. Sensory organs are essential for connecting external stimuli into a biological response, through the senses: sight, smell, taste, hearing, and touch. The G-protein-coupled receptors (GPCRs) are responsible for many of these senses and therefore play a key role in the perception of the cells’ external environment, enabling interaction and coordinated development between each cell of a multicellular organism. The malaria-causing protozoan parasite, <i>Plasmodium falciparum</i>, has a complex life cycle that is extremely dependent on a finely regulated cellular signaling machinery. In this review, we summarize strong evidence and the main candidates of GPCRs in protozoan parasites. Interestingly, one of these GPCRs is a sensor for K<sup>+</sup> shift in <i>Plasmodium falciparum</i>, PfSR25. Studying this family of proteins in <i>P. falciparum</i> could have a significant impact, both on understanding the history of the evolution of GPCRs and on finding new targets for antimalarials.Pedro H. S. PereiraCelia R. S. GarciaMDPI AGarticle<i>Plasmodium falciparum</i>cell signalingGPCRssynchronizationcalciumBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12381, p 12381 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Plasmodium falciparum</i> cell signaling GPCRs synchronization calcium Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	<i>Plasmodium falciparum</i> cell signaling GPCRs synchronization calcium Biology (General) QH301-705.5 Chemistry QD1-999 Pedro H. S. Pereira Celia R. S. Garcia Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
description	Throughout evolution, the need for single-celled organisms to associate and form a single cluster of cells has had several evolutionary advantages. In complex, multicellular organisms, each tissue or organ has a specialty and function that make life together possible, and the organism as a whole needs to act in balance and adapt to changes in the environment. Sensory organs are essential for connecting external stimuli into a biological response, through the senses: sight, smell, taste, hearing, and touch. The G-protein-coupled receptors (GPCRs) are responsible for many of these senses and therefore play a key role in the perception of the cells’ external environment, enabling interaction and coordinated development between each cell of a multicellular organism. The malaria-causing protozoan parasite, <i>Plasmodium falciparum</i>, has a complex life cycle that is extremely dependent on a finely regulated cellular signaling machinery. In this review, we summarize strong evidence and the main candidates of GPCRs in protozoan parasites. Interestingly, one of these GPCRs is a sensor for K<sup>+</sup> shift in <i>Plasmodium falciparum</i>, PfSR25. Studying this family of proteins in <i>P. falciparum</i> could have a significant impact, both on understanding the history of the evolution of GPCRs and on finding new targets for antimalarials.
format	article
author	Pedro H. S. Pereira Celia R. S. Garcia
author_facet	Pedro H. S. Pereira Celia R. S. Garcia
author_sort	Pedro H. S. Pereira
title	Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
title_short	Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
title_full	Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
title_fullStr	Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
title_full_unstemmed	Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit
title_sort	evidence of g-protein-coupled receptors (gpcr) in the parasitic protozoa <i>plasmodium falciparum</i>—sensing the host environment and coupling within its molecular signaling toolkit
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f24a84b2e4da44afa9a858122e0f2005
work_keys_str_mv	AT pedrohspereira evidenceofgproteincoupledreceptorsgpcrintheparasiticprotozoaiplasmodiumfalciparumisensingthehostenvironmentandcouplingwithinitsmolecularsignalingtoolkit AT celiarsgarcia evidenceofgproteincoupledreceptorsgpcrintheparasiticprotozoaiplasmodiumfalciparumisensingthehostenvironmentandcouplingwithinitsmolecularsignalingtoolkit
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Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa <i>Plasmodium falciparum</i>—Sensing the Host Environment and Coupling within Its Molecular Signaling Toolkit

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