Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Abstract A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellen...

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Autores principales:	Guanren Zhao, Ling Long, Lina Zhang, Mingli Peng, Ting Cui, Xiaoxun Wen, Xing Zhou, Lijun Sun, Ling Che
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f24efb2af99c42939f556ba9d51a4be8
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spelling	oai:doaj.org-article:f24efb2af99c42939f556ba9d51a4be82021-12-02T16:06:18ZSmart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery10.1038/s41598-017-03111-22045-2322https://doaj.org/article/f24efb2af99c42939f556ba9d51a4be82017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03111-2https://doaj.org/toc/2045-2322Abstract A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequently, this smart pH-sensitive PEGylation cleavage provided an efficient strategy to target tumor microenvironment, in turn afforded superior therapeutic outcome in anti-tumor activity.Guanren ZhaoLing LongLina ZhangMingli PengTing CuiXiaoxun WenXing ZhouLijun SunLing CheNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guanren Zhao Ling Long Lina Zhang Mingli Peng Ting Cui Xiaoxun Wen Xing Zhou Lijun Sun Ling Che Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
description	Abstract A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequently, this smart pH-sensitive PEGylation cleavage provided an efficient strategy to target tumor microenvironment, in turn afforded superior therapeutic outcome in anti-tumor activity.
format	article
author	Guanren Zhao Ling Long Lina Zhang Mingli Peng Ting Cui Xiaoxun Wen Xing Zhou Lijun Sun Ling Che
author_facet	Guanren Zhao Ling Long Lina Zhang Mingli Peng Ting Cui Xiaoxun Wen Xing Zhou Lijun Sun Ling Che
author_sort	Guanren Zhao
title	Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
title_short	Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
title_full	Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
title_fullStr	Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
title_full_unstemmed	Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery
title_sort	smart ph-sensitive nanoassemblies with cleavable pegylation for tumor targeted drug delivery
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f24efb2af99c42939f556ba9d51a4be8
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Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

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