Auditory resting-state network connectivity in tinnitus: a functional MRI study.

The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI "resting-state" connectivity patterns in auditory network differ betw...

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Autores principales:	Audrey Maudoux, Philippe Lefebvre, Jean-Evrard Cabay, Athena Demertzi, Audrey Vanhaudenhuyse, Steven Laureys, Andrea Soddu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f24fbf913c68455887822941360fe29f
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spelling	oai:doaj.org-article:f24fbf913c68455887822941360fe29f2021-11-18T07:19:40ZAuditory resting-state network connectivity in tinnitus: a functional MRI study.1932-620310.1371/journal.pone.0036222https://doaj.org/article/f24fbf913c68455887822941360fe29f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22574141/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI "resting-state" connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress leading to disabling chronic tinnitus.Audrey MaudouxPhilippe LefebvreJean-Evrard CabayAthena DemertziAudrey VanhaudenhuyseSteven LaureysAndrea SodduPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e36222 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Audrey Maudoux Philippe Lefebvre Jean-Evrard Cabay Athena Demertzi Audrey Vanhaudenhuyse Steven Laureys Andrea Soddu Auditory resting-state network connectivity in tinnitus: a functional MRI study.
description	The underlying functional neuroanatomy of tinnitus remains poorly understood. Few studies have focused on functional cerebral connectivity changes in tinnitus patients. The aim of this study was to test if functional MRI "resting-state" connectivity patterns in auditory network differ between tinnitus patients and normal controls. Thirteen chronic tinnitus subjects and fifteen age-matched healthy controls were studied on a 3 tesla MRI. Connectivity was investigated using independent component analysis and an automated component selection approach taking into account the spatial and temporal properties of each component. Connectivity in extra-auditory regions such as brainstem, basal ganglia/NAc, cerebellum, parahippocampal, right prefrontal, parietal, and sensorimotor areas was found to be increased in tinnitus subjects. The right primary auditory cortex, left prefrontal, left fusiform gyrus, and bilateral occipital regions showed a decreased connectivity in tinnitus. These results show that there is a modification of cortical and subcortical functional connectivity in tinnitus encompassing attentional, mnemonic, and emotional networks. Our data corroborate the hypothesized implication of non-auditory regions in tinnitus physiopathology and suggest that various regions of the brain seem involved in the persistent awareness of the phenomenon as well as in the development of the associated distress leading to disabling chronic tinnitus.
format	article
author	Audrey Maudoux Philippe Lefebvre Jean-Evrard Cabay Athena Demertzi Audrey Vanhaudenhuyse Steven Laureys Andrea Soddu
author_facet	Audrey Maudoux Philippe Lefebvre Jean-Evrard Cabay Athena Demertzi Audrey Vanhaudenhuyse Steven Laureys Andrea Soddu
author_sort	Audrey Maudoux
title	Auditory resting-state network connectivity in tinnitus: a functional MRI study.
title_short	Auditory resting-state network connectivity in tinnitus: a functional MRI study.
title_full	Auditory resting-state network connectivity in tinnitus: a functional MRI study.
title_fullStr	Auditory resting-state network connectivity in tinnitus: a functional MRI study.
title_full_unstemmed	Auditory resting-state network connectivity in tinnitus: a functional MRI study.
title_sort	auditory resting-state network connectivity in tinnitus: a functional mri study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/f24fbf913c68455887822941360fe29f
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Auditory resting-state network connectivity in tinnitus: a functional MRI study.

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