Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification

Endometrial cancer is the most frequent gynecological malignancy, and, although epidemiologically it mainly affects advanced age women, it can also affect young patients who want children and who have not yet completed their procreative project. Fertility sparing treatments are the subject of many s...

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Autores principales:	Anna Franca Cavaliere, Federica Perelli, Simona Zaami, Marco D’Indinosante, Irene Turrini, Marco Giusti, Giuseppe Gullo, Giuseppe Vizzielli, Alberto Mattei, Giovanni Scambia, Annalisa Vidiri, Fabrizio Signore
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endometrial cancer molecular biology fertility sparing obstetric outcomes pregnancy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f2546572e5eb4489915d30e6757d5efc
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spelling	oai:doaj.org-article:f2546572e5eb4489915d30e6757d5efc2021-11-25T17:54:42ZFertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification10.3390/ijms2222122481422-00671661-6596https://doaj.org/article/f2546572e5eb4489915d30e6757d5efc2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12248https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Endometrial cancer is the most frequent gynecological malignancy, and, although epidemiologically it mainly affects advanced age women, it can also affect young patients who want children and who have not yet completed their procreative project. Fertility sparing treatments are the subject of many studies and research in continuous evolution, and represent a light of hope for young cancer patients who find themselves having to face an oncological path before fulfilling their desire for motherhood. The advances in molecular biology and the more precise clinical and prognostic classification of endometrial cancer based on the 2013 The Cancer Genome Atlas classification allow for the selection of patients who can be submitted to fertility sparing treatments with increasing oncological safety. It would also be possible to predict the response to hormonal treatment by investigating the state of the genes of the mismatch repair.Anna Franca CavaliereFederica PerelliSimona ZaamiMarco D’IndinosanteIrene TurriniMarco GiustiGiuseppe GulloGiuseppe VizzielliAlberto MatteiGiovanni ScambiaAnnalisa VidiriFabrizio SignoreMDPI AGarticleendometrial cancermolecular biologyfertility sparingobstetric outcomespregnancyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12248, p 12248 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endometrial cancer molecular biology fertility sparing obstetric outcomes pregnancy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	endometrial cancer molecular biology fertility sparing obstetric outcomes pregnancy Biology (General) QH301-705.5 Chemistry QD1-999 Anna Franca Cavaliere Federica Perelli Simona Zaami Marco D’Indinosante Irene Turrini Marco Giusti Giuseppe Gullo Giuseppe Vizzielli Alberto Mattei Giovanni Scambia Annalisa Vidiri Fabrizio Signore Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification
description	Endometrial cancer is the most frequent gynecological malignancy, and, although epidemiologically it mainly affects advanced age women, it can also affect young patients who want children and who have not yet completed their procreative project. Fertility sparing treatments are the subject of many studies and research in continuous evolution, and represent a light of hope for young cancer patients who find themselves having to face an oncological path before fulfilling their desire for motherhood. The advances in molecular biology and the more precise clinical and prognostic classification of endometrial cancer based on the 2013 The Cancer Genome Atlas classification allow for the selection of patients who can be submitted to fertility sparing treatments with increasing oncological safety. It would also be possible to predict the response to hormonal treatment by investigating the state of the genes of the mismatch repair.
format	article
author	Anna Franca Cavaliere Federica Perelli Simona Zaami Marco D’Indinosante Irene Turrini Marco Giusti Giuseppe Gullo Giuseppe Vizzielli Alberto Mattei Giovanni Scambia Annalisa Vidiri Fabrizio Signore
author_facet	Anna Franca Cavaliere Federica Perelli Simona Zaami Marco D’Indinosante Irene Turrini Marco Giusti Giuseppe Gullo Giuseppe Vizzielli Alberto Mattei Giovanni Scambia Annalisa Vidiri Fabrizio Signore
author_sort	Anna Franca Cavaliere
title	Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification
title_short	Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification
title_full	Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification
title_fullStr	Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification
title_full_unstemmed	Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification
title_sort	fertility sparing treatments in endometrial cancer patients: the potential role of the new molecular classification
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f2546572e5eb4489915d30e6757d5efc
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Fertility Sparing Treatments in Endometrial Cancer Patients: The Potential Role of the New Molecular Classification

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