Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

Abstract The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease acti...

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Autores principales:	Anne-Christine Bay-Jensen, Asger Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Bente Juhl Riis, Claus Christiansen, Martin Michaelis, Hans Guehring, Christoph Ladel, Morten A. Karsdal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2558c7d1f10478b8c5f1554b53e37d1
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spelling	oai:doaj.org-article:f2558c7d1f10478b8c5f1554b53e37d12021-12-02T11:45:01ZSerum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis10.1038/s41598-021-86064-x2045-2322https://doaj.org/article/f2558c7d1f10478b8c5f1554b53e37d12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86064-xhttps://doaj.org/toc/2045-2322Abstract The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease activity and response to treatment in rheumatoid arthritis (RA). We investigated the level of blood CRPM in OA compared to RA using data from two phase III knee OA and two RA studies (N = 1591). Moreover, the association between CRPM levels and radiographic progression was investigated. The mean CRPM levels were significantly lower in OA (8.5 [95% CI 8.3–8.8] ng/mL, n = 781) compared to the RA patients (12.8 [9.5–16.0] ng/mL, n = 60); however, a significant subset of OA patients (31%) had CRPM levels (≥ 9 ng/mL) comparable to RA. Furthermore, OA patients (n = 152) with CRPM levels ≥ 9 ng/mL were more likely to develop contra-lateral knee OA assessed by X-ray over a two-year follow-up period with an odds ratio of 2.2 [1.0–4.7]. These data suggest that CRPM is a blood-based biochemical marker for early identification OA patients with an inflammatory phenotype.Anne-Christine Bay-JensenAsger BihletInger ByrjalsenJeppe Ragnar AndersenBente Juhl RiisClaus ChristiansenMartin MichaelisHans GuehringChristoph LadelMorten A. KarsdalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne-Christine Bay-Jensen Asger Bihlet Inger Byrjalsen Jeppe Ragnar Andersen Bente Juhl Riis Claus Christiansen Martin Michaelis Hans Guehring Christoph Ladel Morten A. Karsdal Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
description	Abstract The heterogeneous nature of osteoarthritis (OA) and the need to subtype patients is widely accepted in the field. The biomarker CRPM, a metabolite of C-reactive protein (CRP), is released to the circulation during inflammation. Blood CRPM levels have shown to be associated with disease activity and response to treatment in rheumatoid arthritis (RA). We investigated the level of blood CRPM in OA compared to RA using data from two phase III knee OA and two RA studies (N = 1591). Moreover, the association between CRPM levels and radiographic progression was investigated. The mean CRPM levels were significantly lower in OA (8.5 [95% CI 8.3–8.8] ng/mL, n = 781) compared to the RA patients (12.8 [9.5–16.0] ng/mL, n = 60); however, a significant subset of OA patients (31%) had CRPM levels (≥ 9 ng/mL) comparable to RA. Furthermore, OA patients (n = 152) with CRPM levels ≥ 9 ng/mL were more likely to develop contra-lateral knee OA assessed by X-ray over a two-year follow-up period with an odds ratio of 2.2 [1.0–4.7]. These data suggest that CRPM is a blood-based biochemical marker for early identification OA patients with an inflammatory phenotype.
format	article
author	Anne-Christine Bay-Jensen Asger Bihlet Inger Byrjalsen Jeppe Ragnar Andersen Bente Juhl Riis Claus Christiansen Martin Michaelis Hans Guehring Christoph Ladel Morten A. Karsdal
author_facet	Anne-Christine Bay-Jensen Asger Bihlet Inger Byrjalsen Jeppe Ragnar Andersen Bente Juhl Riis Claus Christiansen Martin Michaelis Hans Guehring Christoph Ladel Morten A. Karsdal
author_sort	Anne-Christine Bay-Jensen
title	Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
title_short	Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
title_full	Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
title_fullStr	Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
title_full_unstemmed	Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis
title_sort	serum c-reactive protein metabolite (crpm) is associated with incidence of contralateral knee osteoarthritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2558c7d1f10478b8c5f1554b53e37d1
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Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

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