Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains

Abstract Intrathoracic pressure (ITP) swings challenge many physiological systems. The responses of cerebral hemodynamics to different ITP swings are still less well-known due to the complexity of cerebral circulation and methodological limitation. Using frequency-domain near-infrared spectroscopy a...

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Autores principales:	Zhongxing Zhang, Nina Bolz, Marco Laures, Margit Oremek, Christoph Schmidt, Ming Qi, Ramin Khatami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2572f6212b04ef299c2ec1191a2e328
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spelling	oai:doaj.org-article:f2572f6212b04ef299c2ec1191a2e3282021-12-02T16:08:23ZCerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains10.1038/s41598-017-08698-02045-2322https://doaj.org/article/f2572f6212b04ef299c2ec1191a2e3282017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08698-0https://doaj.org/toc/2045-2322Abstract Intrathoracic pressure (ITP) swings challenge many physiological systems. The responses of cerebral hemodynamics to different ITP swings are still less well-known due to the complexity of cerebral circulation and methodological limitation. Using frequency-domain near-infrared spectroscopy and echocardiography, we measured changes in cerebral, muscular and cardiac hemodynamics in five graded respiratory maneuvers (RM), breath holding, moderate and strong Valsalva maneuvers (mVM/sVM) with 20 and 40 cmH2O increments in ITP, moderate and strong Mueller maneuvers (mMM/sMM) with 20 and 40 cmH2O decrements in ITP controlled by esophageal manometry. We found cerebral blood volume (CBV) maintains relative constant during the strains while it increases during the recoveries together with increased oxygen supply. By contrast changes in muscular blood volume (MBV) are mainly controlled by systemic changes. The graded changes of ITP during the maneuvers predict the changes of MBV but not CBV. Changes in left ventricular stroke volume and heart rate correlate to MBV but not to CBV. These results suggest the increased CBV after the ITP strains is brain specific, suggesting cerebral vasodilatation. Within the strains, cerebral oxygen saturation only decreases in sVM, indicating strong increment rather than decrement in ITP may be more challenging for the brain.Zhongxing ZhangNina BolzMarco LauresMargit OremekChristoph SchmidtMing QiRamin KhatamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhongxing Zhang Nina Bolz Marco Laures Margit Oremek Christoph Schmidt Ming Qi Ramin Khatami Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
description	Abstract Intrathoracic pressure (ITP) swings challenge many physiological systems. The responses of cerebral hemodynamics to different ITP swings are still less well-known due to the complexity of cerebral circulation and methodological limitation. Using frequency-domain near-infrared spectroscopy and echocardiography, we measured changes in cerebral, muscular and cardiac hemodynamics in five graded respiratory maneuvers (RM), breath holding, moderate and strong Valsalva maneuvers (mVM/sVM) with 20 and 40 cmH2O increments in ITP, moderate and strong Mueller maneuvers (mMM/sMM) with 20 and 40 cmH2O decrements in ITP controlled by esophageal manometry. We found cerebral blood volume (CBV) maintains relative constant during the strains while it increases during the recoveries together with increased oxygen supply. By contrast changes in muscular blood volume (MBV) are mainly controlled by systemic changes. The graded changes of ITP during the maneuvers predict the changes of MBV but not CBV. Changes in left ventricular stroke volume and heart rate correlate to MBV but not to CBV. These results suggest the increased CBV after the ITP strains is brain specific, suggesting cerebral vasodilatation. Within the strains, cerebral oxygen saturation only decreases in sVM, indicating strong increment rather than decrement in ITP may be more challenging for the brain.
format	article
author	Zhongxing Zhang Nina Bolz Marco Laures Margit Oremek Christoph Schmidt Ming Qi Ramin Khatami
author_facet	Zhongxing Zhang Nina Bolz Marco Laures Margit Oremek Christoph Schmidt Ming Qi Ramin Khatami
author_sort	Zhongxing Zhang
title	Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
title_short	Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
title_full	Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
title_fullStr	Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
title_full_unstemmed	Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
title_sort	cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2572f6212b04ef299c2ec1191a2e328
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Cerebral blood volume and oxygen supply uniformly increase following various intrathoracic pressure strains

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