Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

Chen-xing Qi,1,&ast; Xin Huang,2,&ast; Yan Tong,1 Yin Shen1,3 1Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People’s Republic of China; 2Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang 330006, People’s Republic of China; 3Medical Research...

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Autores principales:	Qi CX, Huang X, Tong Y, Shen Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	intrinsic functional connectivity diabetic retinopathy primary visual area Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/f25967e9bd3c4fe096026e91982683ed
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spelling	oai:doaj.org-article:f25967e9bd3c4fe096026e91982683ed2021-12-02T16:39:55ZAltered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy1178-7007https://doaj.org/article/f25967e9bd3c4fe096026e91982683ed2021-07-01T00:00:00Zhttps://www.dovepress.com/altered-functional-connectivity-strength-of-primary-visual-cortex-in-s-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Chen-xing Qi,1,&ast; Xin Huang,2,&ast; Yan Tong,1 Yin Shen1,3 1Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People’s Republic of China; 2Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang 330006, People’s Republic of China; 3Medical Research Institute, Wuhan University, Wuhan, 430071, Hubei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yin ShenEye Center, Renmin Hospital of Wuhan University, No. 238, Jie Fang Road, Wu Chang District, Wuhan, 430060, Hubei, People’s Republic of ChinaTel +86 13871550513Email yinshen@whu.edu.cnObjective: The purpose of the study was to find the differences in intrinsic functional connectivity (FC) patterns of the primary visual area (V1) among diabetic retinopathy (DR), diabetes mellitus (DM), and healthy controls (HCs) applying resting-state functional magnetic resonance imaging (rs-fMRI).Patients and Methods: Thirty-five subjects with DR (18 males and 17 females), 22 DM (10 males and 12 females) and 38 HCs (16 males and 22 females) matched for sex, age, and education underwent rs-fMRI scanning. Seed-based FC analysis was performed to find the alterations in the intrinsic FC patterns of V1 in DR compared with DM and HCs.Results: The study found that DR patients had a significant lower FC between the bilateral calcarine (CAL)/left lingual gyrus (LING) (BA 17/18) and the left V1, and between the bilateral CAL/left LING (BA 17/18) and the right V1 compared with the HCs. Meanwhile, patients with DR exhibited higher FC strength between the left V1 and the bilateral Caudate/Olfactory/Orbital superior frontal gyrus (OSFG), and between the bilateral Caudate/Olfactory/OSFG (BA 3/4/6) and the right V1. Compared with DM group, patients with DR showed increased FC strength between the right CAL (BA 17/18) and the right V1. DM group exhibited lower FC strength between the left fusiform and the left V1, and between the bilateral CAL and the right V1 when compared with HCs. Moreover, DM group was observed to have higher FC strength between the left superior frontal gyrus and the left V1.Conclusion: Our findings indicated that DR patients exhibited FC disruptions between V1 and higher visual regions at rest, which may reflect the aberrant information communication in the V1 area of DR individuals. The findings offer important insights into the neuromechanism of vision disorder in DR patients.Keywords: intrinsic functional connectivity, diabetic retinopathy, primary visual areaQi CXHuang XTong YShen YDove Medical Pressarticleintrinsic functional connectivitydiabetic retinopathyprimary visual areaSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3209-3219 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intrinsic functional connectivity diabetic retinopathy primary visual area Specialties of internal medicine RC581-951
spellingShingle	intrinsic functional connectivity diabetic retinopathy primary visual area Specialties of internal medicine RC581-951 Qi CX Huang X Tong Y Shen Y Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy
description	Chen-xing Qi,1,&ast; Xin Huang,2,&ast; Yan Tong,1 Yin Shen1,3 1Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People’s Republic of China; 2Department of Ophthalmology, Jiangxi Provincial People’s Hospital, Nanchang 330006, People’s Republic of China; 3Medical Research Institute, Wuhan University, Wuhan, 430071, Hubei, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yin ShenEye Center, Renmin Hospital of Wuhan University, No. 238, Jie Fang Road, Wu Chang District, Wuhan, 430060, Hubei, People’s Republic of ChinaTel +86 13871550513Email yinshen@whu.edu.cnObjective: The purpose of the study was to find the differences in intrinsic functional connectivity (FC) patterns of the primary visual area (V1) among diabetic retinopathy (DR), diabetes mellitus (DM), and healthy controls (HCs) applying resting-state functional magnetic resonance imaging (rs-fMRI).Patients and Methods: Thirty-five subjects with DR (18 males and 17 females), 22 DM (10 males and 12 females) and 38 HCs (16 males and 22 females) matched for sex, age, and education underwent rs-fMRI scanning. Seed-based FC analysis was performed to find the alterations in the intrinsic FC patterns of V1 in DR compared with DM and HCs.Results: The study found that DR patients had a significant lower FC between the bilateral calcarine (CAL)/left lingual gyrus (LING) (BA 17/18) and the left V1, and between the bilateral CAL/left LING (BA 17/18) and the right V1 compared with the HCs. Meanwhile, patients with DR exhibited higher FC strength between the left V1 and the bilateral Caudate/Olfactory/Orbital superior frontal gyrus (OSFG), and between the bilateral Caudate/Olfactory/OSFG (BA 3/4/6) and the right V1. Compared with DM group, patients with DR showed increased FC strength between the right CAL (BA 17/18) and the right V1. DM group exhibited lower FC strength between the left fusiform and the left V1, and between the bilateral CAL and the right V1 when compared with HCs. Moreover, DM group was observed to have higher FC strength between the left superior frontal gyrus and the left V1.Conclusion: Our findings indicated that DR patients exhibited FC disruptions between V1 and higher visual regions at rest, which may reflect the aberrant information communication in the V1 area of DR individuals. The findings offer important insights into the neuromechanism of vision disorder in DR patients.Keywords: intrinsic functional connectivity, diabetic retinopathy, primary visual area
format	article
author	Qi CX Huang X Tong Y Shen Y
author_facet	Qi CX Huang X Tong Y Shen Y
author_sort	Qi CX
title	Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy
title_short	Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy
title_full	Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy
title_fullStr	Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy
title_full_unstemmed	Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy
title_sort	altered functional connectivity strength of primary visual cortex in subjects with diabetic retinopathy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f25967e9bd3c4fe096026e91982683ed
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_version_	1718383609643008000

Altered Functional Connectivity Strength of Primary Visual Cortex in Subjects with Diabetic Retinopathy

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