Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology

Abstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1...

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Autores principales:	Yan Sun, Wei Xu, Ke-Liang Chen, Xue-Ning Shen, Lan Tan, Jin-Tai Yu, for the Alzheimer’s Disease Neuroimaging Initiative
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/f25f5534363148629779ac8f6b828515
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spelling	oai:doaj.org-article:f25f5534363148629779ac8f6b8285152021-11-14T12:11:18ZMild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology10.1038/s41398-021-01675-22158-3188https://doaj.org/article/f25f5534363148629779ac8f6b8285152021-11-01T00:00:00Zhttps://doi.org/10.1038/s41398-021-01675-2https://doaj.org/toc/2158-3188Abstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1129 participants (563 [49.86%] female), who had measures of Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, and amyloid PET AD biomarkers from the Alzheimer’s disease Neuroimaging Initiative (ADNI). We assess the longitudinal neuropathological and clinical correlates of baseline MBI via linear mixed effects and Cox proportional hazard models. The mediation analyses were used to test the mediation effects of AD pathologies on cognition. We found that MBI was associated with worse global cognition as represented by Mini-Mental State Examination (MMSE) (p < 0.001), and higher β-amyloid burden (p < 0.001). β-amyloid partially mediated the effects of MBI on cognition with the mediation percentage varied from 14.67 to 40.86% for general cognition, memory, executive, and language functions for non-dementia individuals. However, no significant associations were discovered between MBI and tau burden or neurodegeneration. Furthermore, longitudinal analyses revealed that individuals with MBI had a faster increase in brain amyloid burden (p < 0.001) and a higher risk of clinical conversion (HR = 2.42, 95% CI = 1.45 to 4.01 p < 0.001). In conclusion, MBI could be an imperative prediction indicator of clinical and pathological progression. In addition, amyloid pathologies might partially mediate the influences of MBI on cognitive impairments and AD risk.Yan SunWei XuKe-Liang ChenXue-Ning ShenLan TanJin-Tai Yufor the Alzheimer’s Disease Neuroimaging InitiativeNature Publishing GrouparticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yan Sun Wei Xu Ke-Liang Chen Xue-Ning Shen Lan Tan Jin-Tai Yu for the Alzheimer’s Disease Neuroimaging Initiative Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
description	Abstract The relationship between mild behavioral impairment (MBI) and Alzheimer’s disease (AD) is intricate and still not well investigated. The purpose of the study is to examine the roles of the AD imaging pathologies in modulating the associations of MBI with cognitive impairments. We analyzed 1129 participants (563 [49.86%] female), who had measures of Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, and amyloid PET AD biomarkers from the Alzheimer’s disease Neuroimaging Initiative (ADNI). We assess the longitudinal neuropathological and clinical correlates of baseline MBI via linear mixed effects and Cox proportional hazard models. The mediation analyses were used to test the mediation effects of AD pathologies on cognition. We found that MBI was associated with worse global cognition as represented by Mini-Mental State Examination (MMSE) (p < 0.001), and higher β-amyloid burden (p < 0.001). β-amyloid partially mediated the effects of MBI on cognition with the mediation percentage varied from 14.67 to 40.86% for general cognition, memory, executive, and language functions for non-dementia individuals. However, no significant associations were discovered between MBI and tau burden or neurodegeneration. Furthermore, longitudinal analyses revealed that individuals with MBI had a faster increase in brain amyloid burden (p < 0.001) and a higher risk of clinical conversion (HR = 2.42, 95% CI = 1.45 to 4.01 p < 0.001). In conclusion, MBI could be an imperative prediction indicator of clinical and pathological progression. In addition, amyloid pathologies might partially mediate the influences of MBI on cognitive impairments and AD risk.
format	article
author	Yan Sun Wei Xu Ke-Liang Chen Xue-Ning Shen Lan Tan Jin-Tai Yu for the Alzheimer’s Disease Neuroimaging Initiative
author_facet	Yan Sun Wei Xu Ke-Liang Chen Xue-Ning Shen Lan Tan Jin-Tai Yu for the Alzheimer’s Disease Neuroimaging Initiative
author_sort	Yan Sun
title	Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
title_short	Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
title_full	Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
title_fullStr	Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
title_full_unstemmed	Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
title_sort	mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f25f5534363148629779ac8f6b828515
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Mild behavioral impairment correlates of cognitive impairments in older adults without dementia: mediation by amyloid pathology

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