The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown poor effectiveness in treating peritoneal carcinomatosis (PC) of gastric origin with a high tumor burden (high peritoneal cancer index), though there are scarce therapy alternatives that are able to improve...
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2021
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oai:doaj.org-article:f260bbe5649748e5b03891fc4715842f2021-11-11T17:40:17ZThe Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications10.3390/jcm102150502077-0383https://doaj.org/article/f260bbe5649748e5b03891fc4715842f2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5050https://doaj.org/toc/2077-0383Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown poor effectiveness in treating peritoneal carcinomatosis (PC) of gastric origin with a high tumor burden (high peritoneal cancer index), though there are scarce therapy alternatives that are able to improve survival. In experimental studies, chimeric antigen receptor-T (CAR-T) cell therapy has shown encouraging results in gastric cancer and is currently being evaluated in several clinical trials. Regarding PC, CAR-T cell therapy has also proven useful in experimental studies, especially when administered intraperitoneally, as this route improves cell distribution and lifespan. Although these results need to be supported by ongoing clinical trials, CAR-T cells are a promising new therapeutic approach to peritoneal metastases from gastric cancer. In this review, we summarize the current evidence of the use of CAR-T cells in gastric cancer and PC of gastric origin.Siyuan QianPedro Villarejo-CamposDamián García-OlmoMDPI AGarticlegastric adenocarcinomaperitoneal carcinomatosisintraperitoneal chemotherapycytoreductive surgeryimmunotherapycell therapyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5050, p 5050 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
gastric adenocarcinoma peritoneal carcinomatosis intraperitoneal chemotherapy cytoreductive surgery immunotherapy cell therapy Medicine R |
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gastric adenocarcinoma peritoneal carcinomatosis intraperitoneal chemotherapy cytoreductive surgery immunotherapy cell therapy Medicine R Siyuan Qian Pedro Villarejo-Campos Damián García-Olmo The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications |
| description |
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown poor effectiveness in treating peritoneal carcinomatosis (PC) of gastric origin with a high tumor burden (high peritoneal cancer index), though there are scarce therapy alternatives that are able to improve survival. In experimental studies, chimeric antigen receptor-T (CAR-T) cell therapy has shown encouraging results in gastric cancer and is currently being evaluated in several clinical trials. Regarding PC, CAR-T cell therapy has also proven useful in experimental studies, especially when administered intraperitoneally, as this route improves cell distribution and lifespan. Although these results need to be supported by ongoing clinical trials, CAR-T cells are a promising new therapeutic approach to peritoneal metastases from gastric cancer. In this review, we summarize the current evidence of the use of CAR-T cells in gastric cancer and PC of gastric origin. |
| format |
article |
| author |
Siyuan Qian Pedro Villarejo-Campos Damián García-Olmo |
| author_facet |
Siyuan Qian Pedro Villarejo-Campos Damián García-Olmo |
| author_sort |
Siyuan Qian |
| title |
The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications |
| title_short |
The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications |
| title_full |
The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications |
| title_fullStr |
The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications |
| title_full_unstemmed |
The Role of CAR-T Cells in Peritoneal Carcinomatosis from Gastric Cancer: Rationale, Experimental Work, and Clinical Applications |
| title_sort |
role of car-t cells in peritoneal carcinomatosis from gastric cancer: rationale, experimental work, and clinical applications |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/f260bbe5649748e5b03891fc4715842f |
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