Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

Abstract Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element w...

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Autores principales:	Nafiseh Baheiraei, Hossein Eyni, Bita Bakhshi, Raziyeh Najafloo, Navid Rabiee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f262e5ea1db14844a3af303cd64d3380
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spelling	oai:doaj.org-article:f262e5ea1db14844a3af303cd64d33802021-12-02T13:39:55ZEffects of strontium ions with potential antibacterial activity on in vivo bone regeneration10.1038/s41598-021-88058-12045-2322https://doaj.org/article/f262e5ea1db14844a3af303cd64d33802021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88058-1https://doaj.org/toc/2045-2322Abstract Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration. In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds after the whole period. Based on the histological results, Gel-BG/Sr exhibited acceleration of early-stage bone formation in vivo. The results of antibacterial investigation for both scaffolds showed complete growth inhibition against Escherichia coli (E. coli). Although Gel-BG revealed no antibacterial effect on Staphylococcus aureus (S. aureus), the Gel-BG/Sr was able to partially inhibit the growth of S. aureus, as detected by threefold reduction in growth index. Our results confirmed that Sr doped BG is a favorable candidate for bone tissue engineering with superior antibacterial activity and bone regeneration capacity compared with similar counterparts having no Sr ion.Nafiseh BaheiraeiHossein EyniBita BakhshiRaziyeh NajaflooNavid RabieeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nafiseh Baheiraei Hossein Eyni Bita Bakhshi Raziyeh Najafloo Navid Rabiee Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
description	Abstract Bioactive glasses (BGs) have attracted added attention in the structure of the scaffolds for bone repair applications. Different metal ions could be doped in BGs to induce specific biological responses. Among these ions, strontium (Sr) is considered as an effective and safe doping element with promising effects on bone formation and regeneration. In this experiment, we evaluated the antibacterial activities of the gelatin-BG (Gel-BG) and Gel-BG/Sr scaffolds in vitro. The osteogenic properties of the prepared scaffolds were also assessed in rabbit calvarial bone defects for 12 weeks. Both scaffolds showed in vivo bone formation during 12 weeks with the newly formed bone area in Gel-BG/Sr scaffold was higher than that in Gel-BG scaffolds after the whole period. Based on the histological results, Gel-BG/Sr exhibited acceleration of early-stage bone formation in vivo. The results of antibacterial investigation for both scaffolds showed complete growth inhibition against Escherichia coli (E. coli). Although Gel-BG revealed no antibacterial effect on Staphylococcus aureus (S. aureus), the Gel-BG/Sr was able to partially inhibit the growth of S. aureus, as detected by threefold reduction in growth index. Our results confirmed that Sr doped BG is a favorable candidate for bone tissue engineering with superior antibacterial activity and bone regeneration capacity compared with similar counterparts having no Sr ion.
format	article
author	Nafiseh Baheiraei Hossein Eyni Bita Bakhshi Raziyeh Najafloo Navid Rabiee
author_facet	Nafiseh Baheiraei Hossein Eyni Bita Bakhshi Raziyeh Najafloo Navid Rabiee
author_sort	Nafiseh Baheiraei
title	Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
title_short	Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
title_full	Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
title_fullStr	Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
title_full_unstemmed	Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
title_sort	effects of strontium ions with potential antibacterial activity on in vivo bone regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f262e5ea1db14844a3af303cd64d3380
work_keys_str_mv	AT nafisehbaheiraei effectsofstrontiumionswithpotentialantibacterialactivityoninvivoboneregeneration AT hosseineyni effectsofstrontiumionswithpotentialantibacterialactivityoninvivoboneregeneration AT bitabakhshi effectsofstrontiumionswithpotentialantibacterialactivityoninvivoboneregeneration AT raziyehnajafloo effectsofstrontiumionswithpotentialantibacterialactivityoninvivoboneregeneration AT navidrabiee effectsofstrontiumionswithpotentialantibacterialactivityoninvivoboneregeneration
_version_	1718392652371591168

Effects of strontium ions with potential antibacterial activity on in vivo bone regeneration

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