Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy

ABSTRACT: This article reports a fatal case of human herpesvirus 6 (HHV-6) myelitis following CD19-targeted chimeric antigen receptor T-cell therapy. Infection from HHV-6 reactivation after haematopoietic stem cell transplant is established, and outside of this population is limited to case reports....

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Autores principales:	Guy Handley, Fareed Khawaja, Divya S. Kondapi, Hun J. Lee, Gregory P. Kaufman, Sattva S. Neelapu, Luis E. Fayad, Sudhakar Tummala, Linda Chi, Paolo Strati, Victor E. Mulanovich
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CAR T-cell therapy Human herpesvirus-6 Myelitis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/f26674c0219d43379909c76b0dc5f313
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spelling	oai:doaj.org-article:f26674c0219d43379909c76b0dc5f3132021-11-30T04:14:23ZHuman herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy1201-971210.1016/j.ijid.2021.09.061https://doaj.org/article/f26674c0219d43379909c76b0dc5f3132021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007694https://doaj.org/toc/1201-9712ABSTRACT: This article reports a fatal case of human herpesvirus 6 (HHV-6) myelitis following CD19-targeted chimeric antigen receptor T-cell therapy. Infection from HHV-6 reactivation after haematopoietic stem cell transplant is established, and outside of this population is limited to case reports. The patient developed cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome that responded to corticosteroids both clinically and on imaging. Subsequently, ascending flaccid paralysis developed, leading to neuromuscular respiratory failure and, ultimately, death. Disease progression was refractory to foscarnet and multiple immunomodulating agents. HHV-6 should be considered in patients with encephalitis and myelitis after adoptive T-cell therapy.Guy HandleyFareed KhawajaDivya S. KondapiHun J. LeeGregory P. KaufmanSattva S. NeelapuLuis E. FayadSudhakar TummalaLinda ChiPaolo StratiVictor E. MulanovichElsevierarticleCAR T-cell therapyHuman herpesvirus-6MyelitisInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 327-329 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CAR T-cell therapy Human herpesvirus-6 Myelitis Infectious and parasitic diseases RC109-216
spellingShingle	CAR T-cell therapy Human herpesvirus-6 Myelitis Infectious and parasitic diseases RC109-216 Guy Handley Fareed Khawaja Divya S. Kondapi Hun J. Lee Gregory P. Kaufman Sattva S. Neelapu Luis E. Fayad Sudhakar Tummala Linda Chi Paolo Strati Victor E. Mulanovich Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
description	ABSTRACT: This article reports a fatal case of human herpesvirus 6 (HHV-6) myelitis following CD19-targeted chimeric antigen receptor T-cell therapy. Infection from HHV-6 reactivation after haematopoietic stem cell transplant is established, and outside of this population is limited to case reports. The patient developed cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome that responded to corticosteroids both clinically and on imaging. Subsequently, ascending flaccid paralysis developed, leading to neuromuscular respiratory failure and, ultimately, death. Disease progression was refractory to foscarnet and multiple immunomodulating agents. HHV-6 should be considered in patients with encephalitis and myelitis after adoptive T-cell therapy.
format	article
author	Guy Handley Fareed Khawaja Divya S. Kondapi Hun J. Lee Gregory P. Kaufman Sattva S. Neelapu Luis E. Fayad Sudhakar Tummala Linda Chi Paolo Strati Victor E. Mulanovich
author_facet	Guy Handley Fareed Khawaja Divya S. Kondapi Hun J. Lee Gregory P. Kaufman Sattva S. Neelapu Luis E. Fayad Sudhakar Tummala Linda Chi Paolo Strati Victor E. Mulanovich
author_sort	Guy Handley
title	Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
title_short	Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
title_full	Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
title_fullStr	Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
title_full_unstemmed	Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
title_sort	human herpesvirus 6 myelitis after chimeric antigen receptor t-cell therapy
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f26674c0219d43379909c76b0dc5f313
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Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy

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