Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis

Rosario Gulias-Cañizo,1 Andres Benatti,2 Guillermo De Wit-Carter,3 Everardo Hernández-Quintela,3 Valeria Sánchez-Huerta3 1Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico; 2Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argen...

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Autores principales:	Gulias-Cañizo R, Benatti A, De Wit-Carter G, Hernández-Quintela E, Sánchez-Huerta V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cross-linking pack-cxl resistant keratitis Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f26aa246806647d9ac19a166469d8ae8
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spelling	oai:doaj.org-article:f26aa246806647d9ac19a166469d8ae82021-12-02T11:57:17ZPhotoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis1177-5483https://doaj.org/article/f26aa246806647d9ac19a166469d8ae82020-12-01T00:00:00Zhttps://www.dovepress.com/photoactivated-chromophore-for-keratitis-corneal-collagen-cross-linkin-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Rosario Gulias-Cañizo,1 Andres Benatti,2 Guillermo De Wit-Carter,3 Everardo Hernández-Quintela,3 Valeria Sánchez-Huerta3 1Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico; 2Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argentina; 3Asociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Mexico City 04030, MexicoCorrespondence: Valeria Sánchez-HuertaAsociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Vicente García Torres 46, San Lucas, Mexico City 04030, MexicoTel +5215525599999Fax +5215510841404Email valeriash@gmail.comPurpose: To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis.Design: Observational cohort study.Participants: Forty-two eyes from 41 patients with treatment-resistant infectious keratitis.Methods: Eyes underwent PACK-CXL treatment with the Dresden modified protocol in addition to standard antimicrobial therapy. The primary endpoint was the size of the corneal ulcer. Descriptive statistics, Wilcoxon rank test, McNemar test and Spearman correlation coefficient were used for statistical analysis, and p values lower than 0.05 were considered statistically significant.Results: Success rate at third postoperative month was of 90.5%. Statistical analyses showed a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size (p=0.031).Conclusion: As adjuvant therapy to standard antimicrobial treatment, PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers.Keywords: cross-linking, PACK-CXL, resistant keratitisGulias-Cañizo RBenatti ADe Wit-Carter GHernández-Quintela ESánchez-Huerta VDove Medical Pressarticlecross-linkingpack-cxlresistant keratitisOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4451-4457 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cross-linking pack-cxl resistant keratitis Ophthalmology RE1-994
spellingShingle	cross-linking pack-cxl resistant keratitis Ophthalmology RE1-994 Gulias-Cañizo R Benatti A De Wit-Carter G Hernández-Quintela E Sánchez-Huerta V Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
description	Rosario Gulias-Cañizo,1 Andres Benatti,2 Guillermo De Wit-Carter,3 Everardo Hernández-Quintela,3 Valeria Sánchez-Huerta3 1Universidad Anahuac Mexico, Huixquilucan, Estado de Mexico, Mexico; 2Cordoba Eye Clinic, Cornea and Refractive Surgery Department, Cordoba, Argentina; 3Asociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Mexico City 04030, MexicoCorrespondence: Valeria Sánchez-HuertaAsociación para Evitar la Ceguera en México, Hospital Dr. Luis Sanchez Bulnes, Cornea Department, Vicente García Torres 46, San Lucas, Mexico City 04030, MexicoTel +5215525599999Fax +5215510841404Email valeriash@gmail.comPurpose: To investigate the efficacy of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis.Design: Observational cohort study.Participants: Forty-two eyes from 41 patients with treatment-resistant infectious keratitis.Methods: Eyes underwent PACK-CXL treatment with the Dresden modified protocol in addition to standard antimicrobial therapy. The primary endpoint was the size of the corneal ulcer. Descriptive statistics, Wilcoxon rank test, McNemar test and Spearman correlation coefficient were used for statistical analysis, and p values lower than 0.05 were considered statistically significant.Results: Success rate at third postoperative month was of 90.5%. Statistical analyses showed a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size (p=0.031).Conclusion: As adjuvant therapy to standard antimicrobial treatment, PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers.Keywords: cross-linking, PACK-CXL, resistant keratitis
format	article
author	Gulias-Cañizo R Benatti A De Wit-Carter G Hernández-Quintela E Sánchez-Huerta V
author_facet	Gulias-Cañizo R Benatti A De Wit-Carter G Hernández-Quintela E Sánchez-Huerta V
author_sort	Gulias-Cañizo R
title	Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
title_short	Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
title_full	Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
title_fullStr	Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
title_full_unstemmed	Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis
title_sort	photoactivated chromophore for keratitis-corneal collagen cross-linking (pack-cxl) improves outcomes of treatment-resistant infectious keratitis
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/f26aa246806647d9ac19a166469d8ae8
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Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) Improves Outcomes of Treatment-Resistant Infectious Keratitis

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