Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

Abstract Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsist...

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Autores principales:	Katarina Vulić, Jovana Bjekić, Dunja Paunović, Miloš Jovanović, Slađan Milanović, Saša R. Filipović
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f26be000ff4d44e28a6b3aed5de173bd
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spelling	oai:doaj.org-article:f26be000ff4d44e28a6b3aed5de173bd2021-12-02T10:44:22ZTheta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory10.1038/s41598-021-82577-72045-2322https://doaj.org/article/f26be000ff4d44e28a6b3aed5de173bd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82577-7https://doaj.org/toc/2045-2322Abstract Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.Katarina VulićJovana BjekićDunja PaunovićMiloš JovanovićSlađan MilanovićSaša R. FilipovićNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarina Vulić Jovana Bjekić Dunja Paunović Miloš Jovanović Slađan Milanović Saša R. Filipović Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
description	Abstract Associative memory (AM) reflects the ability to remember and retrieve multiple pieces of information bound together thus enabling complex episodic experiences. Despite growing interest in the use of transcranial direct current stimulation (tDCS) for the modulation of AM, there are inconsistent evidence regarding its benefits. An alternative to standard constant tDCS could be the application of frequency-modulated tDCS protocols, that mimic natural function-relevant brain rhythms. Here, we show the effects of anodal tDCS oscillating in theta rhythm (5 Hz; 1.5 ± 0.1 mA) versus constant anodal tDCS and sham over left posterior parietal cortex on cued recall of face-word associations. In a crossover design, each participant completed AM assessment immediately following 20-min theta-oscillatory, constant, and sham tDCS, as well as 1 and 5 days after. Theta oscillatory tDCS increased initial AM performance in comparison to sham, and so did constant tDCS. On the group level, no differences between oscillatory and constant tDCS were observed, but individual-level analysis revealed that some participants responded to theta-oscillatory but not to constant tDCS, and vice versa, which could be attributed to their different physiological modes of action. This study shows the potential of oscillatory tDCS protocols for memory enhancement to produce strong and reliable memory-modulating effects which deserve to be investigated further.
format	article
author	Katarina Vulić Jovana Bjekić Dunja Paunović Miloš Jovanović Slađan Milanović Saša R. Filipović
author_facet	Katarina Vulić Jovana Bjekić Dunja Paunović Miloš Jovanović Slađan Milanović Saša R. Filipović
author_sort	Katarina Vulić
title	Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
title_short	Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
title_full	Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
title_fullStr	Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
title_full_unstemmed	Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
title_sort	theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f26be000ff4d44e28a6b3aed5de173bd
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Theta-modulated oscillatory transcranial direct current stimulation over posterior parietal cortex improves associative memory

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