A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.

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Bibliographic Details
Main Authors: Donghai Xiong, Yian Wang, Ming You
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/f272e035b0804ec2a83b8daf7b11d346
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Summary:Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.