A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.

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Détails bibliographiques
Auteurs principaux:	Donghai Xiong, Yian Wang, Ming You
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f272e035b0804ec2a83b8daf7b11d346
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spelling	oai:doaj.org-article:f272e035b0804ec2a83b8daf7b11d3462021-12-02T18:37:17ZA gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response10.1038/s41467-020-18546-x2041-1723https://doaj.org/article/f272e035b0804ec2a83b8daf7b11d3462020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18546-xhttps://doaj.org/toc/2041-1723Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.Donghai XiongYian WangMing YouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Donghai Xiong Yian Wang Ming You A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
description	Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.
format	article
author	Donghai Xiong Yian Wang Ming You
author_facet	Donghai Xiong Yian Wang Ming You
author_sort	Donghai Xiong
title	A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_short	A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_full	A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_fullStr	A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_full_unstemmed	A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response
title_sort	gene expression signature of trem2hi macrophages and γδ t cells predicts immunotherapy response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f272e035b0804ec2a83b8daf7b11d346
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A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

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