Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice

Abstract Tramadol is an opioid extensively used to treat moderate to severe pain; however, prolonged therapy is associated with several tissues damage. Chronic use of tramadol was linked to increased hospitalizations due to cardiovascular complications. Limited literature has described the effects o...

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Autores principales:	Marwa H. Bakr, Eman Radwan, Asmaa S. Shaltout, Alshaimaa A. Farrag, Amany Refaat Mahmoud, Tarek Hamdy Abd-Elhamid, Maha Ali
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2734b0eacba46019ec32c401da19a0c
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spelling	oai:doaj.org-article:f2734b0eacba46019ec32c401da19a0c2021-12-02T17:27:11ZChronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice10.1038/s41598-021-98206-22045-2322https://doaj.org/article/f2734b0eacba46019ec32c401da19a0c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98206-2https://doaj.org/toc/2045-2322Abstract Tramadol is an opioid extensively used to treat moderate to severe pain; however, prolonged therapy is associated with several tissues damage. Chronic use of tramadol was linked to increased hospitalizations due to cardiovascular complications. Limited literature has described the effects of tramadol on the cardiovascular system, so we sought to investigate these actions and elucidate the underlying mechanisms. Mice received tramadol hydrochloride (40 mg/kg body weight) orally for 4 successive weeks. Oxidative stress, inflammation, and cardiac toxicity were assessed. In addition, eNOS expression was evaluated. Our results demonstrated marked histopathological alteration in heart and aortic tissues after exposure to tramadol. Tramadol upregulated the expression of oxidative stress and inflammatory markers in mice heart and aorta, whereas downregulated eNOS expression. Tramadol caused cardiac damage shown by the increase in LDH, Troponin I, and CK-MB activities in serum samples. Overall, these results highlight the risks of tramadol on the cardiovascular system.Marwa H. BakrEman RadwanAsmaa S. ShaltoutAlshaimaa A. FarragAmany Refaat MahmoudTarek Hamdy Abd-ElhamidMaha AliNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marwa H. Bakr Eman Radwan Asmaa S. Shaltout Alshaimaa A. Farrag Amany Refaat Mahmoud Tarek Hamdy Abd-Elhamid Maha Ali Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
description	Abstract Tramadol is an opioid extensively used to treat moderate to severe pain; however, prolonged therapy is associated with several tissues damage. Chronic use of tramadol was linked to increased hospitalizations due to cardiovascular complications. Limited literature has described the effects of tramadol on the cardiovascular system, so we sought to investigate these actions and elucidate the underlying mechanisms. Mice received tramadol hydrochloride (40 mg/kg body weight) orally for 4 successive weeks. Oxidative stress, inflammation, and cardiac toxicity were assessed. In addition, eNOS expression was evaluated. Our results demonstrated marked histopathological alteration in heart and aortic tissues after exposure to tramadol. Tramadol upregulated the expression of oxidative stress and inflammatory markers in mice heart and aorta, whereas downregulated eNOS expression. Tramadol caused cardiac damage shown by the increase in LDH, Troponin I, and CK-MB activities in serum samples. Overall, these results highlight the risks of tramadol on the cardiovascular system.
format	article
author	Marwa H. Bakr Eman Radwan Asmaa S. Shaltout Alshaimaa A. Farrag Amany Refaat Mahmoud Tarek Hamdy Abd-Elhamid Maha Ali
author_facet	Marwa H. Bakr Eman Radwan Asmaa S. Shaltout Alshaimaa A. Farrag Amany Refaat Mahmoud Tarek Hamdy Abd-Elhamid Maha Ali
author_sort	Marwa H. Bakr
title	Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
title_short	Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
title_full	Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
title_fullStr	Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
title_full_unstemmed	Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
title_sort	chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2734b0eacba46019ec32c401da19a0c
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Chronic exposure to tramadol induces cardiac inflammation and endothelial dysfunction in mice

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