Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement

Abstract Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ying-Yi Chen, Yi-Chen Sun, Chia-Ying Tsai, Hsiao-Sang Chu, Jo-Hsuan Wu, Huai-Wen Chang, Wei-Li Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f273f3c6d9174b13a20457ddbe87090f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f273f3c6d9174b13a20457ddbe87090f
record_format	dspace
spelling	oai:doaj.org-article:f273f3c6d9174b13a20457ddbe87090f2021-12-02T17:41:10ZSpectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement10.1038/s41598-021-91999-22045-2322https://doaj.org/article/f273f3c6d9174b13a20457ddbe87090f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91999-2https://doaj.org/toc/2045-2322Abstract Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Eighteen eyes of 10 patients with advancing wavelike epitheliopathy (AWE) and 15 eyes of 9 patients with phlyctenular keratitis/ocular rosacea were recruited. SD-OCT could detect abnormal changes in the POV in 100% of the lesion sites. In presumed-healthy areas of the diseased eyes diagnosed by slit-lamp biomicroscopy, SD-OCT detected abnormal changes in the POV in 100% of the eyes in both groups. In patients with unilateral disease, abnormal changes in the POV were detected by SD-OCT in 50% and 100% of presumed-healthy eyes diagnosed by slit-lamp biomicroscopy in the AWE group and phlyctenular keratitis/ocular rosacea group, respectively. SD-OCT is powerful in detecting POV changes in ocular surface disorders and can provide useful information that cannot be provided by slit-lamp biomicroscopy.Ying-Yi ChenYi-Chen SunChia-Ying TsaiHsiao-Sang ChuJo-Hsuan WuHuai-Wen ChangWei-Li ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying-Yi Chen Yi-Chen Sun Chia-Ying Tsai Hsiao-Sang Chu Jo-Hsuan Wu Huai-Wen Chang Wei-Li Chen Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement
description	Abstract Spectral-domain optical coherence tomography (SD-OCT) has been used to observe the morphology of the palisades of Vogt (POV) with satisfactory resolutions. In this study, we used SD-OCT to examine the microstructure of the POV in ocular surface disorders with limbal involvement. We detect subclinical limbal pathologies based on five parameters, including (1) decreased epithelial thickness, (2) loss of the sharp stromal tip, (3) loss of the smooth epithelial-stromal interface, (4) dilated stromal vessels, and (5) decreased POV density. Eighteen eyes of 10 patients with advancing wavelike epitheliopathy (AWE) and 15 eyes of 9 patients with phlyctenular keratitis/ocular rosacea were recruited. SD-OCT could detect abnormal changes in the POV in 100% of the lesion sites. In presumed-healthy areas of the diseased eyes diagnosed by slit-lamp biomicroscopy, SD-OCT detected abnormal changes in the POV in 100% of the eyes in both groups. In patients with unilateral disease, abnormal changes in the POV were detected by SD-OCT in 50% and 100% of presumed-healthy eyes diagnosed by slit-lamp biomicroscopy in the AWE group and phlyctenular keratitis/ocular rosacea group, respectively. SD-OCT is powerful in detecting POV changes in ocular surface disorders and can provide useful information that cannot be provided by slit-lamp biomicroscopy.
format	article
author	Ying-Yi Chen Yi-Chen Sun Chia-Ying Tsai Hsiao-Sang Chu Jo-Hsuan Wu Huai-Wen Chang Wei-Li Chen
author_facet	Ying-Yi Chen Yi-Chen Sun Chia-Ying Tsai Hsiao-Sang Chu Jo-Hsuan Wu Huai-Wen Chang Wei-Li Chen
author_sort	Ying-Yi Chen
title	Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement
title_short	Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement
title_full	Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement
title_fullStr	Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement
title_full_unstemmed	Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement
title_sort	spectral-domain optical coherence tomography for evaluating palisades of vogt in ocular surface disorders with limbal involvement
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f273f3c6d9174b13a20457ddbe87090f
work_keys_str_mv	AT yingyichen spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement AT yichensun spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement AT chiayingtsai spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement AT hsiaosangchu spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement AT johsuanwu spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement AT huaiwenchang spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement AT weilichen spectraldomainopticalcoherencetomographyforevaluatingpalisadesofvogtinocularsurfacedisorderswithlimbalinvolvement
_version_	1718379739865939968

Spectral-domain optical coherence tomography for evaluating palisades of Vogt in ocular surface disorders with limbal involvement

Ejemplares similares