Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and infl...

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Autores principales:	Sean Matthew McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William Edward Diehl, Jeremy Luban
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2742e3daba04908b834bf421e21448a
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spelling	oai:doaj.org-article:f2742e3daba04908b834bf421e21448a2021-12-02T16:50:09ZIntron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines10.1038/s41467-018-07753-22041-1723https://doaj.org/article/f2742e3daba04908b834bf421e21448a2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07753-2https://doaj.org/toc/2041-1723During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.Sean Matthew McCauleyKyusik KimAnetta NowosielskaAnn DauphinLeonid YurkovetskiyWilliam Edward DiehlJeremy LubanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean Matthew McCauley Kyusik Kim Anetta Nowosielska Ann Dauphin Leonid Yurkovetskiy William Edward Diehl Jeremy Luban Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
description	During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and inflammatory cytokine production.
format	article
author	Sean Matthew McCauley Kyusik Kim Anetta Nowosielska Ann Dauphin Leonid Yurkovetskiy William Edward Diehl Jeremy Luban
author_facet	Sean Matthew McCauley Kyusik Kim Anetta Nowosielska Ann Dauphin Leonid Yurkovetskiy William Edward Diehl Jeremy Luban
author_sort	Sean Matthew McCauley
title	Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
title_short	Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
title_full	Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
title_fullStr	Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
title_full_unstemmed	Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
title_sort	intron-containing rna from the hiv-1 provirus activates type i interferon and inflammatory cytokines
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f2742e3daba04908b834bf421e21448a
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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

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