Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Jing Zhang,1,* Hua Tang,2,* Zefa Liu,2 Baoan Chen1 1Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 2Department of Hematology, People’s Hospital of Xinghua City, Xinghua City, Jiangsu Province, People’s Republic of China...

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Autores principales:	Zhang J, Tang H, Liu Z, Chen B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	nanocarrier parameters chemotherapy drug targeting delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f276bd05162f47a99bbd52c7000b28e0
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spelling	oai:doaj.org-article:f276bd05162f47a99bbd52c7000b28e02021-12-02T05:09:49ZEffects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy1178-2013https://doaj.org/article/f276bd05162f47a99bbd52c7000b28e02017-11-01T00:00:00Zhttps://www.dovepress.com/effects-of-major-parameters-of-nanoparticles-on-their-physical-and-che-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jing Zhang,1,* Hua Tang,2,* Zefa Liu,2 Baoan Chen1 1Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 2Department of Hematology, People’s Hospital of Xinghua City, Xinghua City, Jiangsu Province, People’s Republic of China *These authors contributed equally to this workAbstract: Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.Keywords: nanocarrier, parameters, chemotherapy, drug targeting deliveryZhang JTang HLiu ZChen BDove Medical Pressarticlenanocarrierparameterschemotherapydrug targeting deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8483-8493 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanocarrier parameters chemotherapy drug targeting delivery Medicine (General) R5-920
spellingShingle	nanocarrier parameters chemotherapy drug targeting delivery Medicine (General) R5-920 Zhang J Tang H Liu Z Chen B Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
description	Jing Zhang,1,* Hua Tang,2,* Zefa Liu,2 Baoan Chen1 1Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 2Department of Hematology, People’s Hospital of Xinghua City, Xinghua City, Jiangsu Province, People’s Republic of China *These authors contributed equally to this workAbstract: Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.Keywords: nanocarrier, parameters, chemotherapy, drug targeting delivery
format	article
author	Zhang J Tang H Liu Z Chen B
author_facet	Zhang J Tang H Liu Z Chen B
author_sort	Zhang J
title	Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
title_short	Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
title_full	Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
title_fullStr	Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
title_full_unstemmed	Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
title_sort	effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/f276bd05162f47a99bbd52c7000b28e0
work_keys_str_mv	AT zhangj effectsofmajorparametersofnanoparticlesontheirphysicalandchemicalpropertiesandrecentapplicationofnanodrugdeliverysystemintargetedchemotherapy AT tangh effectsofmajorparametersofnanoparticlesontheirphysicalandchemicalpropertiesandrecentapplicationofnanodrugdeliverysystemintargetedchemotherapy AT liuz effectsofmajorparametersofnanoparticlesontheirphysicalandchemicalpropertiesandrecentapplicationofnanodrugdeliverysystemintargetedchemotherapy AT chenb effectsofmajorparametersofnanoparticlesontheirphysicalandchemicalpropertiesandrecentapplicationofnanodrugdeliverysystemintargetedchemotherapy
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Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

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