Defining the ATPome reveals cross-optimization of metabolic pathways

Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contribute to cellular ATP regulation.

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Detalles Bibliográficos
Autores principales:	Neal K. Bennett, Mai K. Nguyen, Maxwell A. Darch, Hiroki J. Nakaoka, Derek Cousineau, Johanna ten Hoeve, Thomas G. Graeber, Markus Schuelke, Emin Maltepe, Martin Kampmann, Bryce A. Mendelsohn, Jean L. Nakamura, Ken Nakamura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f277e255c7dc4504b568ae47fe3e9af8
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spelling	oai:doaj.org-article:f277e255c7dc4504b568ae47fe3e9af82021-12-02T18:53:15ZDefining the ATPome reveals cross-optimization of metabolic pathways10.1038/s41467-020-18084-62041-1723https://doaj.org/article/f277e255c7dc4504b568ae47fe3e9af82020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18084-6https://doaj.org/toc/2041-1723Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contribute to cellular ATP regulation.Neal K. BennettMai K. NguyenMaxwell A. DarchHiroki J. NakaokaDerek CousineauJohanna ten HoeveThomas G. GraeberMarkus SchuelkeEmin MaltepeMartin KampmannBryce A. MendelsohnJean L. NakamuraKen NakamuraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neal K. Bennett Mai K. Nguyen Maxwell A. Darch Hiroki J. Nakaoka Derek Cousineau Johanna ten Hoeve Thomas G. Graeber Markus Schuelke Emin Maltepe Martin Kampmann Bryce A. Mendelsohn Jean L. Nakamura Ken Nakamura Defining the ATPome reveals cross-optimization of metabolic pathways
description	Energy metabolism and ATP levels are controlled by an interlocking network of pathways. Here, the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define the “ATPome”, a map of pathways that contribute to cellular ATP regulation.
format	article
author	Neal K. Bennett Mai K. Nguyen Maxwell A. Darch Hiroki J. Nakaoka Derek Cousineau Johanna ten Hoeve Thomas G. Graeber Markus Schuelke Emin Maltepe Martin Kampmann Bryce A. Mendelsohn Jean L. Nakamura Ken Nakamura
author_facet	Neal K. Bennett Mai K. Nguyen Maxwell A. Darch Hiroki J. Nakaoka Derek Cousineau Johanna ten Hoeve Thomas G. Graeber Markus Schuelke Emin Maltepe Martin Kampmann Bryce A. Mendelsohn Jean L. Nakamura Ken Nakamura
author_sort	Neal K. Bennett
title	Defining the ATPome reveals cross-optimization of metabolic pathways
title_short	Defining the ATPome reveals cross-optimization of metabolic pathways
title_full	Defining the ATPome reveals cross-optimization of metabolic pathways
title_fullStr	Defining the ATPome reveals cross-optimization of metabolic pathways
title_full_unstemmed	Defining the ATPome reveals cross-optimization of metabolic pathways
title_sort	defining the atpome reveals cross-optimization of metabolic pathways
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f277e255c7dc4504b568ae47fe3e9af8
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Defining the ATPome reveals cross-optimization of metabolic pathways

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