c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

The protein tyrosine kinase c-Src is a renowned proto-oncogene with pleiotropic effects. Here, the authors show that c-Src induces the metabolic reprogramming of cancer cells by phosphorylating hexokinases HK1 and HK2, which in turns lead to increased HK catalytic activity and consequent enhancement...

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Autores principales:	Jia Zhang, Suili Wang, Bin Jiang, Lihong Huang, Zhiliang Ji, Xiaotong Li, Huamin Zhou, Aidong Han, Ai Chen, Yanan Wu, Huanhuan Ma, Wentao Zhao, Qingwen Zhao, Changchuan Xie, Xiaoyan Sun, Yanming Zhou, Huiying Huang, Muhammad Suleman, Furong Lin, Lin Zhou, Fang Tian, Meijun Jin, Yana Cai, Nan Zhang, Qinxi Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f27b5efb81b84ccd82d03b79c90708b3
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spelling	oai:doaj.org-article:f27b5efb81b84ccd82d03b79c90708b32021-12-02T16:51:52Zc-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis10.1038/ncomms137322041-1723https://doaj.org/article/f27b5efb81b84ccd82d03b79c90708b32017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13732https://doaj.org/toc/2041-1723The protein tyrosine kinase c-Src is a renowned proto-oncogene with pleiotropic effects. Here, the authors show that c-Src induces the metabolic reprogramming of cancer cells by phosphorylating hexokinases HK1 and HK2, which in turns lead to increased HK catalytic activity and consequent enhancement of glycolysis.Jia ZhangSuili WangBin JiangLihong HuangZhiliang JiXiaotong LiHuamin ZhouAidong HanAi ChenYanan WuHuanhuan MaWentao ZhaoQingwen ZhaoChangchuan XieXiaoyan SunYanming ZhouHuiying HuangMuhammad SulemanFurong LinLin ZhouFang TianMeijun JinYana CaiNan ZhangQinxi LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jia Zhang Suili Wang Bin Jiang Lihong Huang Zhiliang Ji Xiaotong Li Huamin Zhou Aidong Han Ai Chen Yanan Wu Huanhuan Ma Wentao Zhao Qingwen Zhao Changchuan Xie Xiaoyan Sun Yanming Zhou Huiying Huang Muhammad Suleman Furong Lin Lin Zhou Fang Tian Meijun Jin Yana Cai Nan Zhang Qinxi Li c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
description	The protein tyrosine kinase c-Src is a renowned proto-oncogene with pleiotropic effects. Here, the authors show that c-Src induces the metabolic reprogramming of cancer cells by phosphorylating hexokinases HK1 and HK2, which in turns lead to increased HK catalytic activity and consequent enhancement of glycolysis.
format	article
author	Jia Zhang Suili Wang Bin Jiang Lihong Huang Zhiliang Ji Xiaotong Li Huamin Zhou Aidong Han Ai Chen Yanan Wu Huanhuan Ma Wentao Zhao Qingwen Zhao Changchuan Xie Xiaoyan Sun Yanming Zhou Huiying Huang Muhammad Suleman Furong Lin Lin Zhou Fang Tian Meijun Jin Yana Cai Nan Zhang Qinxi Li
author_facet	Jia Zhang Suili Wang Bin Jiang Lihong Huang Zhiliang Ji Xiaotong Li Huamin Zhou Aidong Han Ai Chen Yanan Wu Huanhuan Ma Wentao Zhao Qingwen Zhao Changchuan Xie Xiaoyan Sun Yanming Zhou Huiying Huang Muhammad Suleman Furong Lin Lin Zhou Fang Tian Meijun Jin Yana Cai Nan Zhang Qinxi Li
author_sort	Jia Zhang
title	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
title_short	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
title_full	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
title_fullStr	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
title_full_unstemmed	c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
title_sort	c-src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f27b5efb81b84ccd82d03b79c90708b3
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c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

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