Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.

Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells.

<h4>Background</h4>VLA-4 and CD38 predict a poor clinical outcome in chronic lymphocytic leukemia (CLL). We used CLL samples with discordant VLA-4/CD38 risk to address their individual roles in human bone marrow infiltration (BM), CLL cell homing to murine BM, and in supportive CLL cell-...

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Main Authors: Gabriele Brachtl, Karine Sahakyan, Ursula Denk, Tamara Girbl, Beate Alinger, Sebastian W Hofbauer, Daniel Neureiter, Josefina Piñón Hofbauer, Alexander Egle, Richard Greil, Tanja Nicole Hartmann
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/f27c2e873cf34c0db3effd3f5f53862a
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