Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria

Tariq Jan,1 Javed Iqbal,1 Muhammad Ismail,2 M Zakaullah,3 Sajjad Haider Naqvi,4 Noor Badshah51Laboratory of Nanoscience and Technology, Department of Physics, International Islamic University, Islamabad, Pakistan; 2Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan; 3Department of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jan T, Iqbal J, Ismail M, Zakaullah M, Naqvi SH, Badshah N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f27cc2cc926745949fd9ef42534c5749
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f27cc2cc926745949fd9ef42534c5749
record_format	dspace
spelling	oai:doaj.org-article:f27cc2cc926745949fd9ef42534c57492021-12-02T04:23:48ZSn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria1176-91141178-2013https://doaj.org/article/f27cc2cc926745949fd9ef42534c57492013-09-01T00:00:00Zhttp://www.dovepress.com/sn-doping-induced-enhancement-in-the-activity-of-zno-nanostructures-ag-a14518https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Tariq Jan,1 Javed Iqbal,1 Muhammad Ismail,2 M Zakaullah,3 Sajjad Haider Naqvi,4 Noor Badshah51Laboratory of Nanoscience and Technology, Department of Physics, International Islamic University, Islamabad, Pakistan; 2Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan; 3Department of Physics, Quaid-i-Azam University, Islamabad, Pakistan; 4Department of Biochemistry, University of Karachi, Karachi, Pakistan; 5Department of Basic Science, University of Engineering and Technology, Peshawar, PakistanAbstract: Highly ionic metal oxide nanostructures are attractive, not only for their physiochemical properties but also for antibacterial activity. Zinc oxide (ZnO) nanostructures are known to have inhibitory activity against many pathogens but very little is known about doping effects on it. The antibacterial activity of undoped ZnO and tin (Sn) doped ZnO nanostructures synthesized by a simple, versatile, and wet chemical technique have been investigated against Escherichia coli, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa bacterial strains. It has been interestingly observed that Sn doping enhanced the inhibitory activity of ZnO against S. aureus more efficiently than the other two bacterial strains. From cytotoxicity and reactive oxygen species (ROS) production studies it is found that Sn doping concentration in ZnO does not alter the cytotoxicity and ROS production very much. It has also been observed that undoped and Sn doped ZnO nanostructures are biosafe and biocompatible materials towards SH-SY5Y Cells. The observed behavior of ZnO nanostructures with Sn doping is a new way to prevent bacterial infections of S. aureus, especially on skin, when using these nanostructures in creams or lotions in addition to their sunscreen property as an ultraviolet filter. Structural investigations have confirmed the formation of a single phase wurtzite structure of ZnO. The morphology of ZnO nanostructures is found to vary from spherical to rod shaped as a function of Sn doping. The excitation absorption peak of ZnO is observed to have a blue shift, with Sn doping leading toward a significant tuning in band gap.Keywords: nanostructures, Sn doped ZnO, S. aureus, antibacterial activityJan TIqbal JIsmail MZakaullah MNaqvi SHBadshah NDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 3679-3687 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jan T Iqbal J Ismail M Zakaullah M Naqvi SH Badshah N Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
description	Tariq Jan,1 Javed Iqbal,1 Muhammad Ismail,2 M Zakaullah,3 Sajjad Haider Naqvi,4 Noor Badshah51Laboratory of Nanoscience and Technology, Department of Physics, International Islamic University, Islamabad, Pakistan; 2Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan; 3Department of Physics, Quaid-i-Azam University, Islamabad, Pakistan; 4Department of Biochemistry, University of Karachi, Karachi, Pakistan; 5Department of Basic Science, University of Engineering and Technology, Peshawar, PakistanAbstract: Highly ionic metal oxide nanostructures are attractive, not only for their physiochemical properties but also for antibacterial activity. Zinc oxide (ZnO) nanostructures are known to have inhibitory activity against many pathogens but very little is known about doping effects on it. The antibacterial activity of undoped ZnO and tin (Sn) doped ZnO nanostructures synthesized by a simple, versatile, and wet chemical technique have been investigated against Escherichia coli, methicillin-resistant Staphylococcus aureus, and Pseudomonas aeruginosa bacterial strains. It has been interestingly observed that Sn doping enhanced the inhibitory activity of ZnO against S. aureus more efficiently than the other two bacterial strains. From cytotoxicity and reactive oxygen species (ROS) production studies it is found that Sn doping concentration in ZnO does not alter the cytotoxicity and ROS production very much. It has also been observed that undoped and Sn doped ZnO nanostructures are biosafe and biocompatible materials towards SH-SY5Y Cells. The observed behavior of ZnO nanostructures with Sn doping is a new way to prevent bacterial infections of S. aureus, especially on skin, when using these nanostructures in creams or lotions in addition to their sunscreen property as an ultraviolet filter. Structural investigations have confirmed the formation of a single phase wurtzite structure of ZnO. The morphology of ZnO nanostructures is found to vary from spherical to rod shaped as a function of Sn doping. The excitation absorption peak of ZnO is observed to have a blue shift, with Sn doping leading toward a significant tuning in band gap.Keywords: nanostructures, Sn doped ZnO, S. aureus, antibacterial activity
format	article
author	Jan T Iqbal J Ismail M Zakaullah M Naqvi SH Badshah N
author_facet	Jan T Iqbal J Ismail M Zakaullah M Naqvi SH Badshah N
author_sort	Jan T
title	Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_short	Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_full	Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_fullStr	Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_full_unstemmed	Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria
title_sort	sn doping induced enhancement in the activity of zno nanostructures against antibiotic resistant s. aureus bacteria
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f27cc2cc926745949fd9ef42534c5749
work_keys_str_mv	AT jant sndopinginducedenhancementintheactivityofznonanostructuresagainstantibioticresistantsaureusbacteria AT iqbalj sndopinginducedenhancementintheactivityofznonanostructuresagainstantibioticresistantsaureusbacteria AT ismailm sndopinginducedenhancementintheactivityofznonanostructuresagainstantibioticresistantsaureusbacteria AT zakaullahm sndopinginducedenhancementintheactivityofznonanostructuresagainstantibioticresistantsaureusbacteria AT naqvish sndopinginducedenhancementintheactivityofznonanostructuresagainstantibioticresistantsaureusbacteria AT badshahn sndopinginducedenhancementintheactivityofznonanostructuresagainstantibioticresistantsaureusbacteria
_version_	1718401284626710528

Sn doping induced enhancement in the activity of ZnO nanostructures against antibiotic resistant S. aureus bacteria

Ejemplares similares