Viral Phrenology

We introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using g...

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Bibliographic Details
Main Authors:	David P. Wilson, Danielle A. Roof
Format:	article
Language:	EN
Published:	MDPI AG 2021
Subjects:	Baltimore Classification virus genome Triangulation number protruding features spherical virus point arrays Microbiology QR1-502
Online Access:	https://doaj.org/article/f27fa9b895c948639c06933902b4ca7d
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id	oai:doaj.org-article:f27fa9b895c948639c06933902b4ca7d
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spelling	oai:doaj.org-article:f27fa9b895c948639c06933902b4ca7d2021-11-25T19:13:13ZViral Phrenology10.3390/v131121911999-4915https://doaj.org/article/f27fa9b895c948639c06933902b4ca7d2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2191https://doaj.org/toc/1999-4915We introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using gauge points of point arrays, we found 149 unique structural protrusions. We then show how to use the locations of these protrusions to determine the genetic composition of the virus. We then show that ssDNA, dsDNA, dsRNA and ssRNA viruses use different arrangements for distributing their protrusions. We also found that Triangulation number is also partially dependent on the structural protrusions. This analysis begins to tie together Baltimore Classification and Triangulation number using point arrays.David P. WilsonDanielle A. RoofMDPI AGarticleBaltimore Classificationvirus genomeTriangulation numberprotruding featuresspherical viruspoint arraysMicrobiologyQR1-502ENViruses, Vol 13, Iss 2191, p 2191 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Baltimore Classification virus genome Triangulation number protruding features spherical virus point arrays Microbiology QR1-502
spellingShingle	Baltimore Classification virus genome Triangulation number protruding features spherical virus point arrays Microbiology QR1-502 David P. Wilson Danielle A. Roof Viral Phrenology
description	We introduce Viral Phrenology, a new scheme for understanding the genomic composition of spherical viruses based on the locations of their structural protrusions. We used icosahedral point arrays to classify 135 distinct viral capsids collected from over 600 capsids available in the VIPERdb. Using gauge points of point arrays, we found 149 unique structural protrusions. We then show how to use the locations of these protrusions to determine the genetic composition of the virus. We then show that ssDNA, dsDNA, dsRNA and ssRNA viruses use different arrangements for distributing their protrusions. We also found that Triangulation number is also partially dependent on the structural protrusions. This analysis begins to tie together Baltimore Classification and Triangulation number using point arrays.
format	article
author	David P. Wilson Danielle A. Roof
author_facet	David P. Wilson Danielle A. Roof
author_sort	David P. Wilson
title	Viral Phrenology
title_short	Viral Phrenology
title_full	Viral Phrenology
title_fullStr	Viral Phrenology
title_full_unstemmed	Viral Phrenology
title_sort	viral phrenology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f27fa9b895c948639c06933902b4ca7d
work_keys_str_mv	AT davidpwilson viralphrenology AT daniellearoof viralphrenology
_version_	1718410190913536000

Viral Phrenology

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