Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis

Abstract It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed...

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Autores principales:	Zhi-Jian Yu, Lu Zeng, Xiang-Qian Luo, Xiao-Rui Geng, Rui Xu, Kun Chen, Gui Yang, Xi Luo, Zhi-Qiang Liu, Zhi-Gang Liu, Da-Bo Liu, Ping-Chang Yang, Hua-Bin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2861f79c8cc4e6ca5921d98374e8606
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spelling	oai:doaj.org-article:f2861f79c8cc4e6ca5921d98374e86062021-12-02T16:06:28ZVitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis10.1038/s41598-017-00431-12045-2322https://doaj.org/article/f2861f79c8cc4e6ca5921d98374e86062017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00431-1https://doaj.org/toc/2045-2322Abstract It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin D3 (VD3) can regulate multiple bioactivities in the body. This study tests a hypothesis that VD3 facilitates the effect of specific immunotherapy (SIT) on Th2 response. We observed that treatment with either SIT or VD3 alleviated AR symptoms as well as reduced serum levels of specific IgE and T helper (Th) 2 cytokines, suppressed miR-19a (one of the members of the miR-17-92 cluster) and increased IL-10 in peripheral B cells, which was further improved in those AR patients treated with both SIT and VD3. The expression of miR-19a and IL-10 was significantly negatively correlated with each other in peripheral B cells of AR patients. Metabolites of VD3 formed a complex with retinoid acid receptor to repress the expression of miR-19a in B cells. We conclude that administration with VD3 promotes the effect of SIT on suppression of AR via repressing the expression of miR-19a in peripheral B cells.Zhi-Jian YuLu ZengXiang-Qian LuoXiao-Rui GengRui XuKun ChenGui YangXi LuoZhi-Qiang LiuZhi-Gang LiuDa-Bo LiuPing-Chang YangHua-Bin LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhi-Jian Yu Lu Zeng Xiang-Qian Luo Xiao-Rui Geng Rui Xu Kun Chen Gui Yang Xi Luo Zhi-Qiang Liu Zhi-Gang Liu Da-Bo Liu Ping-Chang Yang Hua-Bin Li Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
description	Abstract It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin D3 (VD3) can regulate multiple bioactivities in the body. This study tests a hypothesis that VD3 facilitates the effect of specific immunotherapy (SIT) on Th2 response. We observed that treatment with either SIT or VD3 alleviated AR symptoms as well as reduced serum levels of specific IgE and T helper (Th) 2 cytokines, suppressed miR-19a (one of the members of the miR-17-92 cluster) and increased IL-10 in peripheral B cells, which was further improved in those AR patients treated with both SIT and VD3. The expression of miR-19a and IL-10 was significantly negatively correlated with each other in peripheral B cells of AR patients. Metabolites of VD3 formed a complex with retinoid acid receptor to repress the expression of miR-19a in B cells. We conclude that administration with VD3 promotes the effect of SIT on suppression of AR via repressing the expression of miR-19a in peripheral B cells.
format	article
author	Zhi-Jian Yu Lu Zeng Xiang-Qian Luo Xiao-Rui Geng Rui Xu Kun Chen Gui Yang Xi Luo Zhi-Qiang Liu Zhi-Gang Liu Da-Bo Liu Ping-Chang Yang Hua-Bin Li
author_facet	Zhi-Jian Yu Lu Zeng Xiang-Qian Luo Xiao-Rui Geng Rui Xu Kun Chen Gui Yang Xi Luo Zhi-Qiang Liu Zhi-Gang Liu Da-Bo Liu Ping-Chang Yang Hua-Bin Li
author_sort	Zhi-Jian Yu
title	Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_short	Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_full	Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_fullStr	Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_full_unstemmed	Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_sort	vitamin d3 inhibits micro rna-17-92 to promote specific immunotherapy in allergic rhinitis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2861f79c8cc4e6ca5921d98374e8606
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Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis

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