Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection
Here, the authors report that exhausted HCV-specific CD8+ T cells are marked by upregulation of p53 signaling already detectable in an early phase of chronic HCV infection and by a later development of a repressive chromatin state, and show that chemical targeting of these pathways improves CD8+ T c...
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Nature Portfolio
2020
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oai:doaj.org-article:f288f9a480d84b95aefe427ed5f160f32021-12-02T15:39:21ZTargeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection10.1038/s41467-019-14137-72041-1723https://doaj.org/article/f288f9a480d84b95aefe427ed5f160f32020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14137-7https://doaj.org/toc/2041-1723Here, the authors report that exhausted HCV-specific CD8+ T cells are marked by upregulation of p53 signaling already detectable in an early phase of chronic HCV infection and by a later development of a repressive chromatin state, and show that chemical targeting of these pathways improves CD8+ T cell metabolism and antiviral function.Valeria BariliPaola FisicaroBarbara MontaniniGreta AcerbiAnita FilippiGiovanna ForleoChiara RomualdiManuela FerracinFrancesca GuerrieriGiuseppe PedrazziCarolina BoniMarzia RossiAndrea VecchiAmalia PennaAlessandra ZeccaCristina MoriAlessandra OrlandiniElisa NegriMarco PesciMarco MassariGabriele MissaleMassimo LevreroSimone OttonelloCarlo FerrariNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Valeria Barili Paola Fisicaro Barbara Montanini Greta Acerbi Anita Filippi Giovanna Forleo Chiara Romualdi Manuela Ferracin Francesca Guerrieri Giuseppe Pedrazzi Carolina Boni Marzia Rossi Andrea Vecchi Amalia Penna Alessandra Zecca Cristina Mori Alessandra Orlandini Elisa Negri Marco Pesci Marco Massari Gabriele Missale Massimo Levrero Simone Ottonello Carlo Ferrari Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection |
| description |
Here, the authors report that exhausted HCV-specific CD8+ T cells are marked by upregulation of p53 signaling already detectable in an early phase of chronic HCV infection and by a later development of a repressive chromatin state, and show that chemical targeting of these pathways improves CD8+ T cell metabolism and antiviral function. |
| format |
article |
| author |
Valeria Barili Paola Fisicaro Barbara Montanini Greta Acerbi Anita Filippi Giovanna Forleo Chiara Romualdi Manuela Ferracin Francesca Guerrieri Giuseppe Pedrazzi Carolina Boni Marzia Rossi Andrea Vecchi Amalia Penna Alessandra Zecca Cristina Mori Alessandra Orlandini Elisa Negri Marco Pesci Marco Massari Gabriele Missale Massimo Levrero Simone Ottonello Carlo Ferrari |
| author_facet |
Valeria Barili Paola Fisicaro Barbara Montanini Greta Acerbi Anita Filippi Giovanna Forleo Chiara Romualdi Manuela Ferracin Francesca Guerrieri Giuseppe Pedrazzi Carolina Boni Marzia Rossi Andrea Vecchi Amalia Penna Alessandra Zecca Cristina Mori Alessandra Orlandini Elisa Negri Marco Pesci Marco Massari Gabriele Missale Massimo Levrero Simone Ottonello Carlo Ferrari |
| author_sort |
Valeria Barili |
| title |
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection |
| title_short |
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection |
| title_full |
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection |
| title_fullStr |
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection |
| title_full_unstemmed |
Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection |
| title_sort |
targeting p53 and histone methyltransferases restores exhausted cd8+ t cells in hcv infection |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/f288f9a480d84b95aefe427ed5f160f3 |
| work_keys_str_mv |
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