Current available therapies and future directions in the treatment of malignant gliomas

Annick Desjardins1,2, David A Reardon1,3, James J Vredenburgh1,21The Preston Robert Tisch Brain Tumor Center; 2Department of Medicine; 3Department of Surgery, Duke University Medical Center, Durham, NC, USAAbstract: The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However...

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Autores principales: Annick Desjardins, David A Reardon, James J Vredenburgh
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Lenguaje:EN
Publicado: Dove Medical Press 2008
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Acceso en línea:https://doaj.org/article/f28bd4fe4a054f819c5dc43eb35249c7
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spelling oai:doaj.org-article:f28bd4fe4a054f819c5dc43eb35249c72021-12-02T01:51:49ZCurrent available therapies and future directions in the treatment of malignant gliomas1177-54751177-5491https://doaj.org/article/f28bd4fe4a054f819c5dc43eb35249c72008-12-01T00:00:00Zhttp://www.dovepress.com/current-available-therapies-and-future-directions-in-the-treatment-of--a2727https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Annick Desjardins1,2, David A Reardon1,3, James J Vredenburgh1,21The Preston Robert Tisch Brain Tumor Center; 2Department of Medicine; 3Department of Surgery, Duke University Medical Center, Durham, NC, USAAbstract: The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing a better understanding of this particular disease have allowed the development of new therapeutics. Many molecular genetic and signal transduction pathway targets have been identified that are now being investigated. Novel locoregional treatments, as well as strategies to improve regional delivery, are being evaluated. Studies of combinations of these approaches are also underway. In this review, we will discuss the current and future therapies under evaluation for the treatment of malignant gliomas.Keywords: glioma, glioblastoma, targeted therapy, kinase inhibitor Annick DesjardinsDavid A ReardonJames J VredenburghDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2009, Iss default, Pp 15-25 (2008)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Annick Desjardins
David A Reardon
James J Vredenburgh
Current available therapies and future directions in the treatment of malignant gliomas
description Annick Desjardins1,2, David A Reardon1,3, James J Vredenburgh1,21The Preston Robert Tisch Brain Tumor Center; 2Department of Medicine; 3Department of Surgery, Duke University Medical Center, Durham, NC, USAAbstract: The prognosis of patients diagnosed with malignant glioma (MG) remains poor. However, recent advances in neuro-oncology allowing a better understanding of this particular disease have allowed the development of new therapeutics. Many molecular genetic and signal transduction pathway targets have been identified that are now being investigated. Novel locoregional treatments, as well as strategies to improve regional delivery, are being evaluated. Studies of combinations of these approaches are also underway. In this review, we will discuss the current and future therapies under evaluation for the treatment of malignant gliomas.Keywords: glioma, glioblastoma, targeted therapy, kinase inhibitor
format article
author Annick Desjardins
David A Reardon
James J Vredenburgh
author_facet Annick Desjardins
David A Reardon
James J Vredenburgh
author_sort Annick Desjardins
title Current available therapies and future directions in the treatment of malignant gliomas
title_short Current available therapies and future directions in the treatment of malignant gliomas
title_full Current available therapies and future directions in the treatment of malignant gliomas
title_fullStr Current available therapies and future directions in the treatment of malignant gliomas
title_full_unstemmed Current available therapies and future directions in the treatment of malignant gliomas
title_sort current available therapies and future directions in the treatment of malignant gliomas
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/f28bd4fe4a054f819c5dc43eb35249c7
work_keys_str_mv AT annickdesjardins currentavailabletherapiesandfuturedirectionsinthetreatmentofmalignantgliomas
AT davidareardon currentavailabletherapiesandfuturedirectionsinthetreatmentofmalignantgliomas
AT jamesjvredenburgh currentavailabletherapiesandfuturedirectionsinthetreatmentofmalignantgliomas
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