<italic toggle="yes">Toxoplasma</italic> Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion

<italic toggle="yes">Toxoplasma</italic> Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion

ABSTRACT The lysosome-like vacuolar compartment (VAC) is a major site of proteolysis in the intracellular parasite Toxoplasma gondii. Previous studies have shown that genetic ablation of a VAC-residing cysteine protease, cathepsin protease L (CPL), resulted in the accumulation of undigested protein...

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Autores principales: Christian McDonald, David Smith, Manlio Di Cristina, Geetha Kannan, Zhicheng Dou, Vern B. Carruthers
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
Toxoplasma gondii
autophagy
cathepsin
lysosome
proteases
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/f28ca7b56c8f483ca29aa45225b73bdc
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