Long-Lasting T Cell-Independent IgG Responses Require MyD88-Mediated Pathways and Are Maintained by High Levels of Virus Persistence
ABSTRACT Many viruses induce acute T cell-independent (TI) B cell responses due to their repetitive epitopes and the induction of innate cytokines. Nevertheless, T cell help is thought necessary for the development of long-lasting antiviral antibody responses in the form of long-lived plasma cells a...
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Main Authors: | Forum M. Raval, Rabinarayan Mishra, Robert L. Garcea, Raymond M. Welsh, Eva Szomolanyi-Tsuda |
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Format: | article |
Language: | EN |
Published: |
American Society for Microbiology
2013
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Online Access: | https://doaj.org/article/f28fde7ad8614dbcb042ef58ed7ea3f4 |
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