ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES

Angiogenesis factors (VEGF, Ang-1, TGF-β) influence production, development and functioning of vascular endothelium that are part of the placental barrier structure and are involved into transplacental transfer of different substances. The aim of this study was to study the relationship between VEGF...

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Autores principales:	A. D. Shmitko, M. P. Kostinov, V. B. Polyschuk, A. A. Savisko, G. V. Vasilieva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	measles vaccination angiogenesis factors vegf ang-1 tgf-β transplacental antibodies newborns Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/f2919f5d77524733810d62ddfe8d85d7
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spelling	oai:doaj.org-article:f2919f5d77524733810d62ddfe8d85d72021-11-18T08:03:49ZROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES1563-06252313-741X10.15789/1563-0625-2019-5-877-884https://doaj.org/article/f2919f5d77524733810d62ddfe8d85d72019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1730https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAngiogenesis factors (VEGF, Ang-1, TGF-β) influence production, development and functioning of vascular endothelium that are part of the placental barrier structure and are involved into transplacental transfer of different substances. The aim of this study was to study the relationship between VEGF, Ang-1, and TGF-β concentrations, and the levels of transplacental IgG-antibodies to the measles virus in cord blood of children born to mothers with placental insufficiency. Patients and methods: venous blood was taken from 32 women with uncomplicated pregnancies, and 34 samples from pregnant women with placental insufficiency, as well as umbilical blood of their newborns, the level of IgG-antibodies to measles and the concentration of some angiogenic factors (VEGF, Ang-1, TGF-β) examined by ELISA techniques. The following results were obtained: in a cord blood of infants seronegative for the measles virus, born to women with placental insufficiency, showed uniformly low VEGF levels, decreased Ang-1 concentration (1.6) and increased TGF-β concentration (2.7) as compared to seropositive newborns. In a similar group of children from mothers with physiological pregnancy, the level of these factors did not differ from those in newborns with protective antibodies to measles. Conclusion: in physiological pregnancy, transplacental transmission of IgG-antibodies to the measles virus is directly dependent on the presence of specific antibodies in a woman; in case of placental insufficiency, an imbalance in the system of angiogenic factors may promote disturbances of transmission mechanisms for IgG measles-specific antibodies from mother to the fetus.A. D. ShmitkoM. P. KostinovV. B. PolyschukA. A. SaviskoG. V. VasilievaSPb RAACIarticlemeaslesvaccinationangiogenesis factorsvegfang-1tgf-βtransplacental antibodiesnewbornsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 877-884 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	measles vaccination angiogenesis factors vegf ang-1 tgf-β transplacental antibodies newborns Immunologic diseases. Allergy RC581-607
spellingShingle	measles vaccination angiogenesis factors vegf ang-1 tgf-β transplacental antibodies newborns Immunologic diseases. Allergy RC581-607 A. D. Shmitko M. P. Kostinov V. B. Polyschuk A. A. Savisko G. V. Vasilieva ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES
description	Angiogenesis factors (VEGF, Ang-1, TGF-β) influence production, development and functioning of vascular endothelium that are part of the placental barrier structure and are involved into transplacental transfer of different substances. The aim of this study was to study the relationship between VEGF, Ang-1, and TGF-β concentrations, and the levels of transplacental IgG-antibodies to the measles virus in cord blood of children born to mothers with placental insufficiency. Patients and methods: venous blood was taken from 32 women with uncomplicated pregnancies, and 34 samples from pregnant women with placental insufficiency, as well as umbilical blood of their newborns, the level of IgG-antibodies to measles and the concentration of some angiogenic factors (VEGF, Ang-1, TGF-β) examined by ELISA techniques. The following results were obtained: in a cord blood of infants seronegative for the measles virus, born to women with placental insufficiency, showed uniformly low VEGF levels, decreased Ang-1 concentration (1.6) and increased TGF-β concentration (2.7) as compared to seropositive newborns. In a similar group of children from mothers with physiological pregnancy, the level of these factors did not differ from those in newborns with protective antibodies to measles. Conclusion: in physiological pregnancy, transplacental transmission of IgG-antibodies to the measles virus is directly dependent on the presence of specific antibodies in a woman; in case of placental insufficiency, an imbalance in the system of angiogenic factors may promote disturbances of transmission mechanisms for IgG measles-specific antibodies from mother to the fetus.
format	article
author	A. D. Shmitko M. P. Kostinov V. B. Polyschuk A. A. Savisko G. V. Vasilieva
author_facet	A. D. Shmitko M. P. Kostinov V. B. Polyschuk A. A. Savisko G. V. Vasilieva
author_sort	A. D. Shmitko
title	ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES
title_short	ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES
title_full	ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES
title_fullStr	ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES
title_full_unstemmed	ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES
title_sort	role of angiogenic factors for transplacental transfer of the measles antibodies
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/f2919f5d77524733810d62ddfe8d85d7
work_keys_str_mv	AT adshmitko roleofangiogenicfactorsfortransplacentaltransferofthemeaslesantibodies AT mpkostinov roleofangiogenicfactorsfortransplacentaltransferofthemeaslesantibodies AT vbpolyschuk roleofangiogenicfactorsfortransplacentaltransferofthemeaslesantibodies AT aasavisko roleofangiogenicfactorsfortransplacentaltransferofthemeaslesantibodies AT gvvasilieva roleofangiogenicfactorsfortransplacentaltransferofthemeaslesantibodies
_version_	1718422328134598656

ROLE OF ANGIOGENIC FACTORS FOR TRANSPLACENTAL TRANSFER OF THE MEASLES ANTIBODIES

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