Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis

Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis

The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.

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Autores principales: Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das, Anshul Kundaje, Jin Billy Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f291ffe598744dbb9b94da4931988805
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spelling oai:doaj.org-article:f291ffe598744dbb9b94da49319888052021-12-02T14:30:27ZLearning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis10.1038/s41467-021-22489-22041-1723https://doaj.org/article/f291ffe598744dbb9b94da49319888052021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22489-2https://doaj.org/toc/2041-1723The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.Xin LiuTao SunAnna ShcherbinaQin LiInga JarmoskaiteKalli KappelGokul RamaswamiRhiju DasAnshul KundajeJin Billy LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin Liu
Tao Sun
Anna Shcherbina
Qin Li
Inga Jarmoskaite
Kalli Kappel
Gokul Ramaswami
Rhiju Das
Anshul Kundaje
Jin Billy Li
Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
description The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.
format article
author Xin Liu
Tao Sun
Anna Shcherbina
Qin Li
Inga Jarmoskaite
Kalli Kappel
Gokul Ramaswami
Rhiju Das
Anshul Kundaje
Jin Billy Li
author_facet Xin Liu
Tao Sun
Anna Shcherbina
Qin Li
Inga Jarmoskaite
Kalli Kappel
Gokul Ramaswami
Rhiju Das
Anshul Kundaje
Jin Billy Li
author_sort Xin Liu
title Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
title_short Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
title_full Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
title_fullStr Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
title_full_unstemmed Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
title_sort learning cis-regulatory principles of adar-based rna editing from crispr-mediated mutagenesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f291ffe598744dbb9b94da4931988805
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AT annashcherbina learningcisregulatoryprinciplesofadarbasedrnaeditingfromcrisprmediatedmutagenesis
AT qinli learningcisregulatoryprinciplesofadarbasedrnaeditingfromcrisprmediatedmutagenesis
AT ingajarmoskaite learningcisregulatoryprinciplesofadarbasedrnaeditingfromcrisprmediatedmutagenesis
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AT gokulramaswami learningcisregulatoryprinciplesofadarbasedrnaeditingfromcrisprmediatedmutagenesis
AT rhijudas learningcisregulatoryprinciplesofadarbasedrnaeditingfromcrisprmediatedmutagenesis
AT anshulkundaje learningcisregulatoryprinciplesofadarbasedrnaeditingfromcrisprmediatedmutagenesis
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