Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

The development of chemoresistance is a major hurdle in triple negative breast cancer (TNBC). Here, the authors show that lysyl oxidase (LOX) is overexpressed in chemoresistant TNBCs, and when inhibited reduces collagen cross-linking, fibronectin fibril assembly, and downstream integrin signalling,...

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Autores principales:	Ozge Saatci, Aysegul Kaymak, Umar Raza, Pelin G. Ersan, Ozge Akbulut, Carolyn E. Banister, Vitali Sikirzhytski, Unal Metin Tokat, Gamze Aykut, Suhail A. Ansari, Hayriye Tatli Dogan, Mehmet Dogan, Pouria Jandaghi, Aynur Isik, Fatma Gundogdu, Kemal Kosemehmetoglu, Omer Dizdar, Sercan Aksoy, Aytekin Akyol, Aysegul Uner, Phillip J. Buckhaults, Yasser Riazalhosseini, Ozgur Sahin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f292a5a9fd8f4954a8c5c7cfe015c25d
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spelling	oai:doaj.org-article:f292a5a9fd8f4954a8c5c7cfe015c25d2021-12-02T17:16:10ZTargeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer10.1038/s41467-020-16199-42041-1723https://doaj.org/article/f292a5a9fd8f4954a8c5c7cfe015c25d2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16199-4https://doaj.org/toc/2041-1723The development of chemoresistance is a major hurdle in triple negative breast cancer (TNBC). Here, the authors show that lysyl oxidase (LOX) is overexpressed in chemoresistant TNBCs, and when inhibited reduces collagen cross-linking, fibronectin fibril assembly, and downstream integrin signalling, overcoming resistance.Ozge SaatciAysegul KaymakUmar RazaPelin G. ErsanOzge AkbulutCarolyn E. BanisterVitali SikirzhytskiUnal Metin TokatGamze AykutSuhail A. AnsariHayriye Tatli DoganMehmet DoganPouria JandaghiAynur IsikFatma GundogduKemal KosemehmetogluOmer DizdarSercan AksoyAytekin AkyolAysegul UnerPhillip J. BuckhaultsYasser RiazalhosseiniOzgur SahinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ozge Saatci Aysegul Kaymak Umar Raza Pelin G. Ersan Ozge Akbulut Carolyn E. Banister Vitali Sikirzhytski Unal Metin Tokat Gamze Aykut Suhail A. Ansari Hayriye Tatli Dogan Mehmet Dogan Pouria Jandaghi Aynur Isik Fatma Gundogdu Kemal Kosemehmetoglu Omer Dizdar Sercan Aksoy Aytekin Akyol Aysegul Uner Phillip J. Buckhaults Yasser Riazalhosseini Ozgur Sahin Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
description	The development of chemoresistance is a major hurdle in triple negative breast cancer (TNBC). Here, the authors show that lysyl oxidase (LOX) is overexpressed in chemoresistant TNBCs, and when inhibited reduces collagen cross-linking, fibronectin fibril assembly, and downstream integrin signalling, overcoming resistance.
format	article
author	Ozge Saatci Aysegul Kaymak Umar Raza Pelin G. Ersan Ozge Akbulut Carolyn E. Banister Vitali Sikirzhytski Unal Metin Tokat Gamze Aykut Suhail A. Ansari Hayriye Tatli Dogan Mehmet Dogan Pouria Jandaghi Aynur Isik Fatma Gundogdu Kemal Kosemehmetoglu Omer Dizdar Sercan Aksoy Aytekin Akyol Aysegul Uner Phillip J. Buckhaults Yasser Riazalhosseini Ozgur Sahin
author_facet	Ozge Saatci Aysegul Kaymak Umar Raza Pelin G. Ersan Ozge Akbulut Carolyn E. Banister Vitali Sikirzhytski Unal Metin Tokat Gamze Aykut Suhail A. Ansari Hayriye Tatli Dogan Mehmet Dogan Pouria Jandaghi Aynur Isik Fatma Gundogdu Kemal Kosemehmetoglu Omer Dizdar Sercan Aksoy Aytekin Akyol Aysegul Uner Phillip J. Buckhaults Yasser Riazalhosseini Ozgur Sahin
author_sort	Ozge Saatci
title	Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
title_short	Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
title_full	Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
title_fullStr	Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
title_full_unstemmed	Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
title_sort	targeting lysyl oxidase (lox) overcomes chemotherapy resistance in triple negative breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f292a5a9fd8f4954a8c5c7cfe015c25d
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Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer

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