Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering

Tingli Lu,1,* Yuhui Li,1,* Tao Chen1,21Key Laboratory of Space Bioscience and Biotechnology, School of Life Science, Northwestern Polytechnical University, 2Liposome Research Centre, Xi&#39;an, China*These authors contributed equally to this workAbstract: Three-dimensional biomimetic scaffol...

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Autores principales:	Lu T, Li Y, Chen T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f292d299bb5845f59c020b5742d80435
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spelling	oai:doaj.org-article:f292d299bb5845f59c020b5742d804352021-12-02T01:41:00ZTechniques for fabrication and construction of three-dimensional scaffolds for tissue engineering1176-91141178-2013https://doaj.org/article/f292d299bb5845f59c020b5742d804352013-01-01T00:00:00Zhttp://www.dovepress.com/techniques-for-fabrication-and-construction-of-three-dimensional-scaff-a11998https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Tingli Lu,1,* Yuhui Li,1,* Tao Chen1,21Key Laboratory of Space Bioscience and Biotechnology, School of Life Science, Northwestern Polytechnical University, 2Liposome Research Centre, Xi&#39;an, China*These authors contributed equally to this workAbstract: Three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue engineering because of their nanoscaled architecture, eg, nanofibers and nanopores, similar to the native extracellular matrix. In the conventional &ldquo;top-down&rdquo; approach, cells are seeded onto a biocompatible and biodegradable scaffold, in which cells are expected to populate in the scaffold and create their own extracellular matrix. The top-down approach based on these scaffolds has successfully engineered thin tissues, including skin, bladder, and cartilage in vitro. However, it is still a challenge to fabricate complex and functional tissues (eg, liver and kidney) due to the lack of vascularization systems and limited diffusion properties of these large biomimetic scaffolds. The emerging &ldquo;bottom-up&rdquo; method may hold great potential to address these challenges, and focuses on fabricating microscale tissue building blocks with a specific microarchitecture and assembling these units to engineer larger tissue constructs from the bottom up. In this review, state-of-the-art methods for fabrication of three-dimensional biomimetic scaffolds are presented, and their advantages and drawbacks are discussed. The bottom-up methods used to assemble microscale building blocks (eg, microscale hydrogels) for tissue engineering are also reviewed. Finally, perspectives on future development of the bottom-up approach for tissue engineering are addressed.Keywords: three-dimensional, extracellular matrix scaffolds, bottom-up, tissue engineeringLu TLi YChen TDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 337-350 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lu T Li Y Chen T Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
description	Tingli Lu,1,* Yuhui Li,1,* Tao Chen1,21Key Laboratory of Space Bioscience and Biotechnology, School of Life Science, Northwestern Polytechnical University, 2Liposome Research Centre, Xi&#39;an, China*These authors contributed equally to this workAbstract: Three-dimensional biomimetic scaffolds have widespread applications in biomedical tissue engineering because of their nanoscaled architecture, eg, nanofibers and nanopores, similar to the native extracellular matrix. In the conventional &ldquo;top-down&rdquo; approach, cells are seeded onto a biocompatible and biodegradable scaffold, in which cells are expected to populate in the scaffold and create their own extracellular matrix. The top-down approach based on these scaffolds has successfully engineered thin tissues, including skin, bladder, and cartilage in vitro. However, it is still a challenge to fabricate complex and functional tissues (eg, liver and kidney) due to the lack of vascularization systems and limited diffusion properties of these large biomimetic scaffolds. The emerging &ldquo;bottom-up&rdquo; method may hold great potential to address these challenges, and focuses on fabricating microscale tissue building blocks with a specific microarchitecture and assembling these units to engineer larger tissue constructs from the bottom up. In this review, state-of-the-art methods for fabrication of three-dimensional biomimetic scaffolds are presented, and their advantages and drawbacks are discussed. The bottom-up methods used to assemble microscale building blocks (eg, microscale hydrogels) for tissue engineering are also reviewed. Finally, perspectives on future development of the bottom-up approach for tissue engineering are addressed.Keywords: three-dimensional, extracellular matrix scaffolds, bottom-up, tissue engineering
format	article
author	Lu T Li Y Chen T
author_facet	Lu T Li Y Chen T
author_sort	Lu T
title	Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
title_short	Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
title_full	Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
title_fullStr	Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
title_full_unstemmed	Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
title_sort	techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f292d299bb5845f59c020b5742d80435
work_keys_str_mv	AT lut techniquesforfabricationandconstructionofthreedimensionalscaffoldsfortissueengineering AT liy techniquesforfabricationandconstructionofthreedimensionalscaffoldsfortissueengineering AT chent techniquesforfabricationandconstructionofthreedimensionalscaffoldsfortissueengineering
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Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering

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