Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals

Abstract Growth differentiation factors 1 (GDF1) and 3 (GDF3) are members of the transforming growth factor superfamily (TGF-β) that is involved in fundamental early-developmental processes that are conserved across vertebrates. The evolutionary history of these genes is still under debate due to am...

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Autores principales:	Juan C. Opazo, Kattina Zavala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Growth Differentiation Factors 1 (GDF1) Independent Origin Independent Duplication Events Transforming Growth Factor Superfamily Homology Relationships Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2980738ab464c9d870569c531b3cd1c
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spelling	oai:doaj.org-article:f2980738ab464c9d870569c531b3cd1c2021-12-02T15:08:27ZPhylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals10.1038/s41598-018-31954-w2045-2322https://doaj.org/article/f2980738ab464c9d870569c531b3cd1c2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31954-whttps://doaj.org/toc/2045-2322Abstract Growth differentiation factors 1 (GDF1) and 3 (GDF3) are members of the transforming growth factor superfamily (TGF-β) that is involved in fundamental early-developmental processes that are conserved across vertebrates. The evolutionary history of these genes is still under debate due to ambiguous definitions of homologous relationships among vertebrates. Thus, the goal of this study was to unravel the evolution of the GDF1 and GDF3 genes of vertebrates, emphasizing the understanding of homologous relationships and their evolutionary origin. Our results revealed that the GDF1 and GDF3 genes found in anurans and mammals are the products of independent duplication events of an ancestral gene in the ancestor of each of these lineages. The main implication of this result is that the GDF1 and GDF3 genes of anurans and mammals are not 1:1 orthologs. In other words, genes that participate in fundamental processes during early development have been reinvented two independent times during the evolutionary history of tetrapods.Juan C. OpazoKattina ZavalaNature PortfolioarticleGrowth Differentiation Factors 1 (GDF1)Independent OriginIndependent Duplication EventsTransforming Growth Factor SuperfamilyHomology RelationshipsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Growth Differentiation Factors 1 (GDF1) Independent Origin Independent Duplication Events Transforming Growth Factor Superfamily Homology Relationships Medicine R Science Q
spellingShingle	Growth Differentiation Factors 1 (GDF1) Independent Origin Independent Duplication Events Transforming Growth Factor Superfamily Homology Relationships Medicine R Science Q Juan C. Opazo Kattina Zavala Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals
description	Abstract Growth differentiation factors 1 (GDF1) and 3 (GDF3) are members of the transforming growth factor superfamily (TGF-β) that is involved in fundamental early-developmental processes that are conserved across vertebrates. The evolutionary history of these genes is still under debate due to ambiguous definitions of homologous relationships among vertebrates. Thus, the goal of this study was to unravel the evolution of the GDF1 and GDF3 genes of vertebrates, emphasizing the understanding of homologous relationships and their evolutionary origin. Our results revealed that the GDF1 and GDF3 genes found in anurans and mammals are the products of independent duplication events of an ancestral gene in the ancestor of each of these lineages. The main implication of this result is that the GDF1 and GDF3 genes of anurans and mammals are not 1:1 orthologs. In other words, genes that participate in fundamental processes during early development have been reinvented two independent times during the evolutionary history of tetrapods.
format	article
author	Juan C. Opazo Kattina Zavala
author_facet	Juan C. Opazo Kattina Zavala
author_sort	Juan C. Opazo
title	Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals
title_short	Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals
title_full	Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals
title_fullStr	Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals
title_full_unstemmed	Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals
title_sort	phylogenetic evidence for independent origins of gdf1 and gdf3 genes in anurans and mammals
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f2980738ab464c9d870569c531b3cd1c
work_keys_str_mv	AT juancopazo phylogeneticevidenceforindependentoriginsofgdf1andgdf3genesinanuransandmammals AT kattinazavala phylogeneticevidenceforindependentoriginsofgdf1andgdf3genesinanuransandmammals
_version_	1718388162176221184

Phylogenetic evidence for independent origins of GDF1 and GDF3 genes in anurans and mammals

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