Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy

Abstract Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes has been suggested. We applied polychromatic polarization microscopy to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aiste Vitkunaite, Aida Laurinaviciene, Benoit Plancoulaine, Allan Rasmusson, Richard Levenson, Michael Shribak, Arvydas Laurinavicius
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f29807e5e1934452a9e42d9e08df331a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f29807e5e1934452a9e42d9e08df331a
record_format	dspace
spelling	oai:doaj.org-article:f29807e5e1934452a9e42d9e08df331a2021-12-02T11:39:47ZIntranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy10.1038/s41598-021-85667-82045-2322https://doaj.org/article/f29807e5e1934452a9e42d9e08df331a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85667-8https://doaj.org/toc/2045-2322Abstract Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes has been suggested. We applied polychromatic polarization microscopy to image their spatial organization. Our study provides evidence that IBI are caused by liquid paraffin-macromolecular crystals formed during paraffin-embedding procedures within cells and potentially reflect an active transcriptional status.Aiste VitkunaiteAida LaurinavicieneBenoit PlancoulaineAllan RasmussonRichard LevensonMichael ShribakArvydas LaurinaviciusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aiste Vitkunaite Aida Laurinaviciene Benoit Plancoulaine Allan Rasmusson Richard Levenson Michael Shribak Arvydas Laurinavicius Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
description	Abstract Intranuclear birefringent inclusions (IBI) found in various cell types in paraffin-embedded tissue sections have long been considered to be a tissue processing artifact, although an association with biological processes has been suggested. We applied polychromatic polarization microscopy to image their spatial organization. Our study provides evidence that IBI are caused by liquid paraffin-macromolecular crystals formed during paraffin-embedding procedures within cells and potentially reflect an active transcriptional status.
format	article
author	Aiste Vitkunaite Aida Laurinaviciene Benoit Plancoulaine Allan Rasmusson Richard Levenson Michael Shribak Arvydas Laurinavicius
author_facet	Aiste Vitkunaite Aida Laurinaviciene Benoit Plancoulaine Allan Rasmusson Richard Levenson Michael Shribak Arvydas Laurinavicius
author_sort	Aiste Vitkunaite
title	Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
title_short	Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
title_full	Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
title_fullStr	Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
title_full_unstemmed	Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
title_sort	intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f29807e5e1934452a9e42d9e08df331a
work_keys_str_mv	AT aistevitkunaite intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy AT aidalaurinaviciene intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy AT benoitplancoulaine intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy AT allanrasmusson intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy AT richardlevenson intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy AT michaelshribak intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy AT arvydaslaurinavicius intranuclearbirefringentinclusionsinparaffinsectionsbypolychromaticpolarizationmicroscopy
_version_	1718395738097975296

Intranuclear birefringent inclusions in paraffin sections by polychromatic polarization microscopy

Ejemplares similares