An integrated map of HIV-human protein complexes that facilitate viral infection.

Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and can be used as a starting point for further functi...

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Autores principales:	Dorothea Emig-Agius, Kevin Olivieri, Lars Pache, Hsin Ling Shih, Olga Pustovalova, Marina Bessarabova, John A T Young, Sumit K Chanda, Trey Ideker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f29cbe97aeba42728eb5a4c5791daa8b
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spelling	oai:doaj.org-article:f29cbe97aeba42728eb5a4c5791daa8b2021-11-18T08:19:52ZAn integrated map of HIV-human protein complexes that facilitate viral infection.1932-620310.1371/journal.pone.0096687https://doaj.org/article/f29cbe97aeba42728eb5a4c5791daa8b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24817247/?tool=EBIhttps://doaj.org/toc/1932-6203Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and can be used as a starting point for further functional analyses. We integrated this network with complementary datasets of protein function and interaction to nominate human protein complexes with likely roles in viral infection. Based on our approach we identified a global map of 40 HIV-human protein complexes with putative roles in HIV infection, some of which are involved in DNA replication and repair, transcription, translation, and cytoskeletal regulation. Targeted RNAi screens were used to validate several proteins and complexes for functional impact on viral infection. Thus, our HIV-human protein complex map provides a significant resource of potential HIV-host interactions for further study.Dorothea Emig-AgiusKevin OlivieriLars PacheHsin Ling ShihOlga PustovalovaMarina BessarabovaJohn A T YoungSumit K ChandaTrey IdekerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96687 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dorothea Emig-Agius Kevin Olivieri Lars Pache Hsin Ling Shih Olga Pustovalova Marina Bessarabova John A T Young Sumit K Chanda Trey Ideker An integrated map of HIV-human protein complexes that facilitate viral infection.
description	Recent proteomic and genetic studies have aimed to identify a complete network of interactions between HIV and human proteins and genes. This HIV-human interaction network provides invaluable information as to how HIV exploits the host machinery and can be used as a starting point for further functional analyses. We integrated this network with complementary datasets of protein function and interaction to nominate human protein complexes with likely roles in viral infection. Based on our approach we identified a global map of 40 HIV-human protein complexes with putative roles in HIV infection, some of which are involved in DNA replication and repair, transcription, translation, and cytoskeletal regulation. Targeted RNAi screens were used to validate several proteins and complexes for functional impact on viral infection. Thus, our HIV-human protein complex map provides a significant resource of potential HIV-host interactions for further study.
format	article
author	Dorothea Emig-Agius Kevin Olivieri Lars Pache Hsin Ling Shih Olga Pustovalova Marina Bessarabova John A T Young Sumit K Chanda Trey Ideker
author_facet	Dorothea Emig-Agius Kevin Olivieri Lars Pache Hsin Ling Shih Olga Pustovalova Marina Bessarabova John A T Young Sumit K Chanda Trey Ideker
author_sort	Dorothea Emig-Agius
title	An integrated map of HIV-human protein complexes that facilitate viral infection.
title_short	An integrated map of HIV-human protein complexes that facilitate viral infection.
title_full	An integrated map of HIV-human protein complexes that facilitate viral infection.
title_fullStr	An integrated map of HIV-human protein complexes that facilitate viral infection.
title_full_unstemmed	An integrated map of HIV-human protein complexes that facilitate viral infection.
title_sort	integrated map of hiv-human protein complexes that facilitate viral infection.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f29cbe97aeba42728eb5a4c5791daa8b
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An integrated map of HIV-human protein complexes that facilitate viral infection.

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