Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.

The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, such influences on recovery after spinal cord injur...

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Autores principales:	Lukasz P Slomnicki, George Wei, Darlene A Burke, Emily R Hodges, Scott A Myers, Christine D Yarberry, Johnny R Morehouse, Scott R Whittemore, Sujata Saraswat Ohri, Michal Hetman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f29cd798582847b9bb759213f45b5360
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spelling	oai:doaj.org-article:f29cd798582847b9bb759213f45b53602021-12-02T20:16:14ZLimited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.1932-620310.1371/journal.pone.0249981https://doaj.org/article/f29cd798582847b9bb759213f45b53602021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0249981https://doaj.org/toc/1932-6203The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, such influences on recovery after spinal cord injury (SCI) are unknown. We report that mice receiving moderate, T9 contusive SCI at ZT0 (zeitgeber time 0, time of lights on) and ZT12 (time of lights off) showed similar hindlimb function recovery in the Basso mouse scale (BMS) over a 6 week post-injury period. In an independent study, no significant differences in BMS were observed after SCI at ZT18 vs. ZT6. However, the ladder walking test revealed modestly improved performance for ZT18 vs. ZT6 mice at week 6 after injury. Consistent with those minor effects on functional recovery, terminal histological analysis revealed no significant differences in white matter sparing at the injury epicenter. Likewise, blood-spinal cord barrier disruption and neuroinflammation appeared similar when analyzed at 1 week post injury at ZT6 or ZT18. Therefore, locomotor recovery after thoracic contusive SCI is not substantively modulated by the time of day at which the neurotrauma occurred.Lukasz P SlomnickiGeorge WeiDarlene A BurkeEmily R HodgesScott A MyersChristine D YarberryJohnny R MorehouseScott R WhittemoreSujata Saraswat OhriMichal HetmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0249981 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lukasz P Slomnicki George Wei Darlene A Burke Emily R Hodges Scott A Myers Christine D Yarberry Johnny R Morehouse Scott R Whittemore Sujata Saraswat Ohri Michal Hetman Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
description	The circadian gene expression rhythmicity drives diurnal oscillations of physiological processes that may determine the injury response. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, such influences on recovery after spinal cord injury (SCI) are unknown. We report that mice receiving moderate, T9 contusive SCI at ZT0 (zeitgeber time 0, time of lights on) and ZT12 (time of lights off) showed similar hindlimb function recovery in the Basso mouse scale (BMS) over a 6 week post-injury period. In an independent study, no significant differences in BMS were observed after SCI at ZT18 vs. ZT6. However, the ladder walking test revealed modestly improved performance for ZT18 vs. ZT6 mice at week 6 after injury. Consistent with those minor effects on functional recovery, terminal histological analysis revealed no significant differences in white matter sparing at the injury epicenter. Likewise, blood-spinal cord barrier disruption and neuroinflammation appeared similar when analyzed at 1 week post injury at ZT6 or ZT18. Therefore, locomotor recovery after thoracic contusive SCI is not substantively modulated by the time of day at which the neurotrauma occurred.
format	article
author	Lukasz P Slomnicki George Wei Darlene A Burke Emily R Hodges Scott A Myers Christine D Yarberry Johnny R Morehouse Scott R Whittemore Sujata Saraswat Ohri Michal Hetman
author_facet	Lukasz P Slomnicki George Wei Darlene A Burke Emily R Hodges Scott A Myers Christine D Yarberry Johnny R Morehouse Scott R Whittemore Sujata Saraswat Ohri Michal Hetman
author_sort	Lukasz P Slomnicki
title	Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
title_short	Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
title_full	Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
title_fullStr	Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
title_full_unstemmed	Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
title_sort	limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/f29cd798582847b9bb759213f45b5360
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Limited changes in locomotor recovery and unaffected white matter sparing after spinal cord contusion at different times of day.

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