IL-10 signaling blockade controls murine West Nile virus infection.

West Nile virus (WNV), a mosquito-borne single-stranded RNA flavivirus, can cause significant human morbidity and mortality. Our data show that interleukin-10 (IL-10) is dramatically elevated both in vitro and in vivo following WNV infection. Consistent with an etiologic role of IL-10 in WNV pathoge...

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Autores principales:	Fengwei Bai, Terrence Town, Feng Qian, Penghua Wang, Masahito Kamanaka, Tarah M Connolly, David Gate, Ruth R Montgomery, Richard A Flavell, Erol Fikrig
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f2a00660ec054627be1aec5dbbaf7445
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spelling	oai:doaj.org-article:f2a00660ec054627be1aec5dbbaf74452021-11-25T05:47:35ZIL-10 signaling blockade controls murine West Nile virus infection.1553-73661553-737410.1371/journal.ppat.1000610https://doaj.org/article/f2a00660ec054627be1aec5dbbaf74452009-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19816558/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374West Nile virus (WNV), a mosquito-borne single-stranded RNA flavivirus, can cause significant human morbidity and mortality. Our data show that interleukin-10 (IL-10) is dramatically elevated both in vitro and in vivo following WNV infection. Consistent with an etiologic role of IL-10 in WNV pathogenesis, we find that WNV infection is markedly diminished in IL-10 deficient (IL-10(-/-)) mice, and pharmacologic blockade of IL-10 signaling by IL-10 neutralizing antibody increases survival of WNV-infected mice. Increased production of antiviral cytokines in IL-10(-/-) mice is associated with more efficient control of WNV infection. Moreover, CD4(+) T cells produce copious amounts of IL-10, and may be an important cellular source of IL-10 during WNV infection in vivo. In conclusion, IL-10 signaling plays a negative role in immunity against WNV infection, and blockade of IL-10 signaling by genetic or pharmacologic means helps to control viral infection, suggesting a novel anti-WNV therapeutic strategy.Fengwei BaiTerrence TownFeng QianPenghua WangMasahito KamanakaTarah M ConnollyDavid GateRuth R MontgomeryRichard A FlavellErol FikrigPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 10, p e1000610 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Fengwei Bai Terrence Town Feng Qian Penghua Wang Masahito Kamanaka Tarah M Connolly David Gate Ruth R Montgomery Richard A Flavell Erol Fikrig IL-10 signaling blockade controls murine West Nile virus infection.
description	West Nile virus (WNV), a mosquito-borne single-stranded RNA flavivirus, can cause significant human morbidity and mortality. Our data show that interleukin-10 (IL-10) is dramatically elevated both in vitro and in vivo following WNV infection. Consistent with an etiologic role of IL-10 in WNV pathogenesis, we find that WNV infection is markedly diminished in IL-10 deficient (IL-10(-/-)) mice, and pharmacologic blockade of IL-10 signaling by IL-10 neutralizing antibody increases survival of WNV-infected mice. Increased production of antiviral cytokines in IL-10(-/-) mice is associated with more efficient control of WNV infection. Moreover, CD4(+) T cells produce copious amounts of IL-10, and may be an important cellular source of IL-10 during WNV infection in vivo. In conclusion, IL-10 signaling plays a negative role in immunity against WNV infection, and blockade of IL-10 signaling by genetic or pharmacologic means helps to control viral infection, suggesting a novel anti-WNV therapeutic strategy.
format	article
author	Fengwei Bai Terrence Town Feng Qian Penghua Wang Masahito Kamanaka Tarah M Connolly David Gate Ruth R Montgomery Richard A Flavell Erol Fikrig
author_facet	Fengwei Bai Terrence Town Feng Qian Penghua Wang Masahito Kamanaka Tarah M Connolly David Gate Ruth R Montgomery Richard A Flavell Erol Fikrig
author_sort	Fengwei Bai
title	IL-10 signaling blockade controls murine West Nile virus infection.
title_short	IL-10 signaling blockade controls murine West Nile virus infection.
title_full	IL-10 signaling blockade controls murine West Nile virus infection.
title_fullStr	IL-10 signaling blockade controls murine West Nile virus infection.
title_full_unstemmed	IL-10 signaling blockade controls murine West Nile virus infection.
title_sort	il-10 signaling blockade controls murine west nile virus infection.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/f2a00660ec054627be1aec5dbbaf7445
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IL-10 signaling blockade controls murine West Nile virus infection.

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