Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

Rhizoma polygonati (Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors...

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Autores principales:	Yingqiu Xie, Chengling Mu, Bexultan Kazybay, Qinglei Sun, Aidana Kutzhanova, Guldan Nazarbek, Na Xu, Lazzat Nurtay, Qian Wang, Amr Amin, Xugang Li
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	huangjing herbzyme traditional chinese medicine Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/f2a02c020a0f4891a310a941d0e3e811
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spelling	oai:doaj.org-article:f2a02c020a0f4891a310a941d0e3e8112021-11-04T15:00:41ZNetwork pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery1071-75441521-046410.1080/10717544.2021.1977422https://doaj.org/article/f2a02c020a0f4891a310a941d0e3e8112021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/10717544.2021.1977422https://doaj.org/toc/1071-7544https://doaj.org/toc/1521-0464Rhizoma polygonati (Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors in anti-cell growth and blockade in pathways targeting kinases. Experimental investigation and network pharmacology analysis were applied to test the potent kinase-mediated signaling. Herbzyme activity was determined by substrate with optical density measurement. Extract of processed RP inhibits cell growth in a much greater manner than alone when applied in combination with inhibitors of mTOR or EGFR. Moreover, processing methods of RP from Mount Tai (RP-Mount Tai) play essential roles in herbzyme activity of phosphatase suggesting the interface is also essential, in addition to the chemical component. The network pharmacology analysis showed the chemical component and target networks involving AKT and mTOR, which is consistent with experimental validation. Finally, EGFR inhibitor could be associated with nano-extract of RP-Mount Tai but not significantly affects the phosphatase herbzyme activity in vitro. Thus the processed extract of RP-Mount Tai may play a dual role in the inhibition of cell proliferation signaling by both chemical component and nanoscale herbzyme of phosphatase activity to inhibit kinases including mTOR/AKT in potent drug delivery of kinase inhibitors.Yingqiu XieChengling MuBexultan KazybayQinglei SunAidana KutzhanovaGuldan NazarbekNa XuLazzat NurtayQian WangAmr AminXugang LiTaylor & Francis Grouparticlehuangjingherbzymetraditional chinese medicineTherapeutics. PharmacologyRM1-950ENDrug Delivery, Vol 28, Iss 1, Pp 2187-2197 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	huangjing herbzyme traditional chinese medicine Therapeutics. Pharmacology RM1-950
spellingShingle	huangjing herbzyme traditional chinese medicine Therapeutics. Pharmacology RM1-950 Yingqiu Xie Chengling Mu Bexultan Kazybay Qinglei Sun Aidana Kutzhanova Guldan Nazarbek Na Xu Lazzat Nurtay Qian Wang Amr Amin Xugang Li Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
description	Rhizoma polygonati (Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors in anti-cell growth and blockade in pathways targeting kinases. Experimental investigation and network pharmacology analysis were applied to test the potent kinase-mediated signaling. Herbzyme activity was determined by substrate with optical density measurement. Extract of processed RP inhibits cell growth in a much greater manner than alone when applied in combination with inhibitors of mTOR or EGFR. Moreover, processing methods of RP from Mount Tai (RP-Mount Tai) play essential roles in herbzyme activity of phosphatase suggesting the interface is also essential, in addition to the chemical component. The network pharmacology analysis showed the chemical component and target networks involving AKT and mTOR, which is consistent with experimental validation. Finally, EGFR inhibitor could be associated with nano-extract of RP-Mount Tai but not significantly affects the phosphatase herbzyme activity in vitro. Thus the processed extract of RP-Mount Tai may play a dual role in the inhibition of cell proliferation signaling by both chemical component and nanoscale herbzyme of phosphatase activity to inhibit kinases including mTOR/AKT in potent drug delivery of kinase inhibitors.
format	article
author	Yingqiu Xie Chengling Mu Bexultan Kazybay Qinglei Sun Aidana Kutzhanova Guldan Nazarbek Na Xu Lazzat Nurtay Qian Wang Amr Amin Xugang Li
author_facet	Yingqiu Xie Chengling Mu Bexultan Kazybay Qinglei Sun Aidana Kutzhanova Guldan Nazarbek Na Xu Lazzat Nurtay Qian Wang Amr Amin Xugang Li
author_sort	Yingqiu Xie
title	Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
title_short	Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
title_full	Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
title_fullStr	Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
title_full_unstemmed	Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
title_sort	network pharmacology and experimental investigation of rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/f2a02c020a0f4891a310a941d0e3e811
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Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

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