Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain
Abstract Sparse data exist on the complex natural immunity to SARS-CoV-2 at the population level. We applied a well-validated multiplex serology test in 5000 participants of a general population study in Catalonia in blood samples collected from end June to mid November 2020. Based on responses to f...
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Nature Portfolio
2021
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oai:doaj.org-article:f2a24c1a840445babe5765c88320b2fc2021-11-08T10:46:05ZInfection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain10.1038/s41598-021-00807-42045-2322https://doaj.org/article/f2a24c1a840445babe5765c88320b2fc2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00807-4https://doaj.org/toc/2045-2322Abstract Sparse data exist on the complex natural immunity to SARS-CoV-2 at the population level. We applied a well-validated multiplex serology test in 5000 participants of a general population study in Catalonia in blood samples collected from end June to mid November 2020. Based on responses to fifteen isotype-antigen combinations, we detected a seroprevalence of 18.1% in adults (n = 4740), and modeled extrapolation to the general population of Catalonia indicated a 15.3% seroprevalence. Antibodies persisted up to 9 months after infection. Immune profiling of infected individuals revealed that with increasing severity of infection (asymptomatic, 1–3 symptoms, ≥ 4 symptoms, admitted to hospital/ICU), seroresponses were more robust and rich with a shift towards IgG over IgA and anti-spike over anti-nucleocapsid responses. Among seropositive participants, lower antibody levels were observed for those ≥ 60 years vs < 60 years old and smokers vs non-smokers. Overweight/obese participants vs normal weight had higher antibody levels. Adolescents (13–15 years old) (n = 260) showed a seroprevalence of 11.5%, were less likely to be tested seropositive compared to their parents and had dominant anti-spike rather than anti-nucleocapsid IgG responses. Our study provides an unbiased estimate of SARS-CoV-2 seroprevalence in Catalonia and new evidence on the durability and heterogeneity of post-infection immunity.Marianna KarachaliouGemma MoncunillAna EspinosaGemma Castaño-VinyalsAlfons JiménezMarta VidalRebeca SantanoDiana BarriosLaura PuyolAnna CarrerasLeonie MayerRocío RubioBeatriz CortésVanessa PleguezuelosCristina O’Callaghan-GordoSerena FossatiIoar RivasDelphine CasabonneMartine VrijheidLuis IzquierdoRuth AguilarXavier BasagañaJudith Garcia-AymerichRafael de CidCarlota DobañoManolis KogevinasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Marianna Karachaliou Gemma Moncunill Ana Espinosa Gemma Castaño-Vinyals Alfons Jiménez Marta Vidal Rebeca Santano Diana Barrios Laura Puyol Anna Carreras Leonie Mayer Rocío Rubio Beatriz Cortés Vanessa Pleguezuelos Cristina O’Callaghan-Gordo Serena Fossati Ioar Rivas Delphine Casabonne Martine Vrijheid Luis Izquierdo Ruth Aguilar Xavier Basagaña Judith Garcia-Aymerich Rafael de Cid Carlota Dobaño Manolis Kogevinas Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain |
| description |
Abstract Sparse data exist on the complex natural immunity to SARS-CoV-2 at the population level. We applied a well-validated multiplex serology test in 5000 participants of a general population study in Catalonia in blood samples collected from end June to mid November 2020. Based on responses to fifteen isotype-antigen combinations, we detected a seroprevalence of 18.1% in adults (n = 4740), and modeled extrapolation to the general population of Catalonia indicated a 15.3% seroprevalence. Antibodies persisted up to 9 months after infection. Immune profiling of infected individuals revealed that with increasing severity of infection (asymptomatic, 1–3 symptoms, ≥ 4 symptoms, admitted to hospital/ICU), seroresponses were more robust and rich with a shift towards IgG over IgA and anti-spike over anti-nucleocapsid responses. Among seropositive participants, lower antibody levels were observed for those ≥ 60 years vs < 60 years old and smokers vs non-smokers. Overweight/obese participants vs normal weight had higher antibody levels. Adolescents (13–15 years old) (n = 260) showed a seroprevalence of 11.5%, were less likely to be tested seropositive compared to their parents and had dominant anti-spike rather than anti-nucleocapsid IgG responses. Our study provides an unbiased estimate of SARS-CoV-2 seroprevalence in Catalonia and new evidence on the durability and heterogeneity of post-infection immunity. |
| format |
article |
| author |
Marianna Karachaliou Gemma Moncunill Ana Espinosa Gemma Castaño-Vinyals Alfons Jiménez Marta Vidal Rebeca Santano Diana Barrios Laura Puyol Anna Carreras Leonie Mayer Rocío Rubio Beatriz Cortés Vanessa Pleguezuelos Cristina O’Callaghan-Gordo Serena Fossati Ioar Rivas Delphine Casabonne Martine Vrijheid Luis Izquierdo Ruth Aguilar Xavier Basagaña Judith Garcia-Aymerich Rafael de Cid Carlota Dobaño Manolis Kogevinas |
| author_facet |
Marianna Karachaliou Gemma Moncunill Ana Espinosa Gemma Castaño-Vinyals Alfons Jiménez Marta Vidal Rebeca Santano Diana Barrios Laura Puyol Anna Carreras Leonie Mayer Rocío Rubio Beatriz Cortés Vanessa Pleguezuelos Cristina O’Callaghan-Gordo Serena Fossati Ioar Rivas Delphine Casabonne Martine Vrijheid Luis Izquierdo Ruth Aguilar Xavier Basagaña Judith Garcia-Aymerich Rafael de Cid Carlota Dobaño Manolis Kogevinas |
| author_sort |
Marianna Karachaliou |
| title |
Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain |
| title_short |
Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain |
| title_full |
Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain |
| title_fullStr |
Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain |
| title_full_unstemmed |
Infection induced SARS-CoV-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in Catalonia Spain |
| title_sort |
infection induced sars-cov-2 seroprevalence and heterogeneity of antibody responses in a general population cohort study in catalonia spain |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/f2a24c1a840445babe5765c88320b2fc |
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