Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.

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Autores principales:	Melissa Birol, Sunil Kumar, Elizabeth Rhoades, Andrew D. Miranker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2a78bf4814f4244804640673a15eb52
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spelling	oai:doaj.org-article:f2a78bf4814f4244804640673a15eb522021-12-02T15:34:40ZConformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid10.1038/s41467-018-03651-92041-1723https://doaj.org/article/f2a78bf4814f4244804640673a15eb522018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03651-9https://doaj.org/toc/2041-1723Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.Melissa BirolSunil KumarElizabeth RhoadesAndrew D. MirankerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melissa Birol Sunil Kumar Elizabeth Rhoades Andrew D. Miranker Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
description	Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.
format	article
author	Melissa Birol Sunil Kumar Elizabeth Rhoades Andrew D. Miranker
author_facet	Melissa Birol Sunil Kumar Elizabeth Rhoades Andrew D. Miranker
author_sort	Melissa Birol
title	Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
title_short	Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
title_full	Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
title_fullStr	Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
title_full_unstemmed	Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
title_sort	conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f2a78bf4814f4244804640673a15eb52
work_keys_str_mv	AT melissabirol conformationalswitchingwithindynamicoligomersunderpinstoxicgainoffunctionbydiabetesassociatedamyloid AT sunilkumar conformationalswitchingwithindynamicoligomersunderpinstoxicgainoffunctionbydiabetesassociatedamyloid AT elizabethrhoades conformationalswitchingwithindynamicoligomersunderpinstoxicgainoffunctionbydiabetesassociatedamyloid AT andrewdmiranker conformationalswitchingwithindynamicoligomersunderpinstoxicgainoffunctionbydiabetesassociatedamyloid
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Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

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