Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.
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Autores principales: | Melissa Birol, Sunil Kumar, Elizabeth Rhoades, Andrew D. Miranker |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
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Materias: | |
Acceso en línea: | https://doaj.org/article/f2a78bf4814f4244804640673a15eb52 |
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