Ventilatory response to hypercapnia is increased after 4 h of head down bed rest

Abstract Head-down bed rest (HDBR) has previously been shown to alter cerebrovascular and autonomic control. Previous work found that sustained HDBR (≥ 20 days) attenuates the hypercapnic ventilatory response (HCVR); however, little is known about shorter-term effects of HDBR nor the influence of HD...

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Autores principales:	K. R. Murray, S. Wasef, Heather Edgell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2ad075e0b2a441cbf0804c9d6a4b80e
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spelling	oai:doaj.org-article:f2ad075e0b2a441cbf0804c9d6a4b80e2021-12-02T10:48:32ZVentilatory response to hypercapnia is increased after 4 h of head down bed rest10.1038/s41598-021-81837-w2045-2322https://doaj.org/article/f2ad075e0b2a441cbf0804c9d6a4b80e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81837-whttps://doaj.org/toc/2045-2322Abstract Head-down bed rest (HDBR) has previously been shown to alter cerebrovascular and autonomic control. Previous work found that sustained HDBR (≥ 20 days) attenuates the hypercapnic ventilatory response (HCVR); however, little is known about shorter-term effects of HDBR nor the influence of HDBR on the hypoxic ventilatory response (HVR). We investigated the effect of 4-h HDBR on HCVR and HVR and hypothesized attenuated ventilatory responses due to greater carotid and brain blood flow. Cardiorespiratory responses of young men (n = 11) and women (n = 3) to 5% CO2 or 10% O2 before and after 4-h HDBR were examined. HDBR resulted in lower HR, lower cardiac output index, lower common carotid artery flow, higher SpO2, and higher pulse wave velocity. After HDBR, tidal volume and ventilation responses to 5% CO2 were enhanced (all P < 0.05), yet no other changes in cardiorespiratory variables were evident. There was no influence of HDBR on the cardiorespiratory responses to hypoxia (all P > 0.05). Short-duration HDBR does not alter the HVR, yet enhances the HCVR, which we hypothesize is a consequence of cephalic CO2 accumulation from cerebral congestion.K. R. MurrayS. WasefHeather EdgellNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K. R. Murray S. Wasef Heather Edgell Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
description	Abstract Head-down bed rest (HDBR) has previously been shown to alter cerebrovascular and autonomic control. Previous work found that sustained HDBR (≥ 20 days) attenuates the hypercapnic ventilatory response (HCVR); however, little is known about shorter-term effects of HDBR nor the influence of HDBR on the hypoxic ventilatory response (HVR). We investigated the effect of 4-h HDBR on HCVR and HVR and hypothesized attenuated ventilatory responses due to greater carotid and brain blood flow. Cardiorespiratory responses of young men (n = 11) and women (n = 3) to 5% CO2 or 10% O2 before and after 4-h HDBR were examined. HDBR resulted in lower HR, lower cardiac output index, lower common carotid artery flow, higher SpO2, and higher pulse wave velocity. After HDBR, tidal volume and ventilation responses to 5% CO2 were enhanced (all P < 0.05), yet no other changes in cardiorespiratory variables were evident. There was no influence of HDBR on the cardiorespiratory responses to hypoxia (all P > 0.05). Short-duration HDBR does not alter the HVR, yet enhances the HCVR, which we hypothesize is a consequence of cephalic CO2 accumulation from cerebral congestion.
format	article
author	K. R. Murray S. Wasef Heather Edgell
author_facet	K. R. Murray S. Wasef Heather Edgell
author_sort	K. R. Murray
title	Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
title_short	Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
title_full	Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
title_fullStr	Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
title_full_unstemmed	Ventilatory response to hypercapnia is increased after 4 h of head down bed rest
title_sort	ventilatory response to hypercapnia is increased after 4 h of head down bed rest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2ad075e0b2a441cbf0804c9d6a4b80e
work_keys_str_mv	AT krmurray ventilatoryresponsetohypercapniaisincreasedafter4hofheaddownbedrest AT swasef ventilatoryresponsetohypercapniaisincreasedafter4hofheaddownbedrest AT heatheredgell ventilatoryresponsetohypercapniaisincreasedafter4hofheaddownbedrest
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Ventilatory response to hypercapnia is increased after 4 h of head down bed rest

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