Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.

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Detalles Bibliográficos
Autores principales: Melina Mathur, Cameron M. Kim, Sarah A. Munro, Shireen S. Rudina, Eric M. Sawyer, Christina D. Smolke
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/f2ae05290582465fb58220b0ccf48cb8
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Descripción
Sumario:Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.