Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.

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Autores principales:	Melina Mathur, Cameron M. Kim, Sarah A. Munro, Shireen S. Rudina, Eric M. Sawyer, Christina D. Smolke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2ae05290582465fb58220b0ccf48cb8
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spelling	oai:doaj.org-article:f2ae05290582465fb58220b0ccf48cb82021-12-02T17:02:09ZProgrammable mutually exclusive alternative splicing for generating RNA and protein diversity10.1038/s41467-019-10403-w2041-1723https://doaj.org/article/f2ae05290582465fb58220b0ccf48cb82019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10403-whttps://doaj.org/toc/2041-1723Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.Melina MathurCameron M. KimSarah A. MunroShireen S. RudinaEric M. SawyerChristina D. SmolkeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melina Mathur Cameron M. Kim Sarah A. Munro Shireen S. Rudina Eric M. Sawyer Christina D. Smolke Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
description	Alternative splicing expands the genetic coding capacity and proteomic diversity of the cell. Here the authors create a synthetic biology platform for regulating four programmable exons in modular transcription factors.
format	article
author	Melina Mathur Cameron M. Kim Sarah A. Munro Shireen S. Rudina Eric M. Sawyer Christina D. Smolke
author_facet	Melina Mathur Cameron M. Kim Sarah A. Munro Shireen S. Rudina Eric M. Sawyer Christina D. Smolke
author_sort	Melina Mathur
title	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_short	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_full	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_fullStr	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_full_unstemmed	Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
title_sort	programmable mutually exclusive alternative splicing for generating rna and protein diversity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f2ae05290582465fb58220b0ccf48cb8
work_keys_str_mv	AT melinamathur programmablemutuallyexclusivealternativesplicingforgeneratingrnaandproteindiversity AT cameronmkim programmablemutuallyexclusivealternativesplicingforgeneratingrnaandproteindiversity AT sarahamunro programmablemutuallyexclusivealternativesplicingforgeneratingrnaandproteindiversity AT shireensrudina programmablemutuallyexclusivealternativesplicingforgeneratingrnaandproteindiversity AT ericmsawyer programmablemutuallyexclusivealternativesplicingforgeneratingrnaandproteindiversity AT christinadsmolke programmablemutuallyexclusivealternativesplicingforgeneratingrnaandproteindiversity
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Programmable mutually exclusive alternative splicing for generating RNA and protein diversity

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