Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity

Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcript...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alessia Loffreda, Emanuela Jacchetti, Sofia Antunes, Paolo Rainone, Tiziana Daniele, Tatsuya Morisaki, Marco E. Bianchi, Carlo Tacchetti, Davide Mazza
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2aea08fe9e3479693ecf280fdffb669
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2aea08fe9e3479693ecf280fdffb669
record_format	dspace
spelling	oai:doaj.org-article:f2aea08fe9e3479693ecf280fdffb6692021-12-02T13:57:54ZLive-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity10.1038/s41467-017-00398-72041-1723https://doaj.org/article/f2aea08fe9e3479693ecf280fdffb6692017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00398-7https://doaj.org/toc/2041-1723Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity.Alessia LoffredaEmanuela JacchettiSofia AntunesPaolo RainoneTiziana DanieleTatsuya MorisakiMarco E. BianchiCarlo TacchettiDavide MazzaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessia Loffreda Emanuela Jacchetti Sofia Antunes Paolo Rainone Tiziana Daniele Tatsuya Morisaki Marco E. Bianchi Carlo Tacchetti Davide Mazza Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
description	Both transcription binding kinetics and post-translational modifications of transcription factors are thought to play a role in the modulation of transcription. Here the authors use single-molecule tracking to directly demonstrate that p53 acetylation modulates promoter residence time and transcriptional activity.
format	article
author	Alessia Loffreda Emanuela Jacchetti Sofia Antunes Paolo Rainone Tiziana Daniele Tatsuya Morisaki Marco E. Bianchi Carlo Tacchetti Davide Mazza
author_facet	Alessia Loffreda Emanuela Jacchetti Sofia Antunes Paolo Rainone Tiziana Daniele Tatsuya Morisaki Marco E. Bianchi Carlo Tacchetti Davide Mazza
author_sort	Alessia Loffreda
title	Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
title_short	Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
title_full	Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
title_fullStr	Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
title_full_unstemmed	Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity
title_sort	live-cell p53 single-molecule binding is modulated by c-terminal acetylation and correlates with transcriptional activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2aea08fe9e3479693ecf280fdffb669
work_keys_str_mv	AT alessialoffreda livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT emanuelajacchetti livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT sofiaantunes livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT paolorainone livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT tizianadaniele livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT tatsuyamorisaki livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT marcoebianchi livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT carlotacchetti livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity AT davidemazza livecellp53singlemoleculebindingismodulatedbycterminalacetylationandcorrelateswithtranscriptionalactivity
_version_	1718392295203536896

Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity

Ejemplares similares