Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches

Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates Wnt ligands to promote gastrointestinal regeneratio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ji-Eun Kim, Lijiang Fei, Wen-Chi Yin, Sabrina Coquenlorge, Abilasha Rao-Bhatia, Xiaoyun Zhang, Sammy Shun Wai Shi, Ju Hee Lee, Noah A. Hahn, Wasi Rizvi, Kyoung-Han Kim, Hoon-Ki Sung, Chi-chung Hui, Guoji Guo, Tae-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f2afc39b87d4469eb7631c0d62df5b58
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2afc39b87d4469eb7631c0d62df5b58
record_format	dspace
spelling	oai:doaj.org-article:f2afc39b87d4469eb7631c0d62df5b582021-12-02T16:50:03ZSingle cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches10.1038/s41467-019-14058-52041-1723https://doaj.org/article/f2afc39b87d4469eb7631c0d62df5b582020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14058-5https://doaj.org/toc/2041-1723Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates Wnt ligands to promote gastrointestinal regeneration and development.Ji-Eun KimLijiang FeiWen-Chi YinSabrina CoquenlorgeAbilasha Rao-BhatiaXiaoyun ZhangSammy Shun Wai ShiJu Hee LeeNoah A. HahnWasi RizviKyoung-Han KimHoon-Ki SungChi-chung HuiGuoji GuoTae-Hee KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji-Eun Kim Lijiang Fei Wen-Chi Yin Sabrina Coquenlorge Abilasha Rao-Bhatia Xiaoyun Zhang Sammy Shun Wai Shi Ju Hee Lee Noah A. Hahn Wasi Rizvi Kyoung-Han Kim Hoon-Ki Sung Chi-chung Hui Guoji Guo Tae-Hee Kim Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
description	Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates Wnt ligands to promote gastrointestinal regeneration and development.
format	article
author	Ji-Eun Kim Lijiang Fei Wen-Chi Yin Sabrina Coquenlorge Abilasha Rao-Bhatia Xiaoyun Zhang Sammy Shun Wai Shi Ju Hee Lee Noah A. Hahn Wasi Rizvi Kyoung-Han Kim Hoon-Ki Sung Chi-chung Hui Guoji Guo Tae-Hee Kim
author_facet	Ji-Eun Kim Lijiang Fei Wen-Chi Yin Sabrina Coquenlorge Abilasha Rao-Bhatia Xiaoyun Zhang Sammy Shun Wai Shi Ju Hee Lee Noah A. Hahn Wasi Rizvi Kyoung-Han Kim Hoon-Ki Sung Chi-chung Hui Guoji Guo Tae-Hee Kim
author_sort	Ji-Eun Kim
title	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
title_short	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
title_full	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
title_fullStr	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
title_full_unstemmed	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
title_sort	single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f2afc39b87d4469eb7631c0d62df5b58
work_keys_str_mv	AT jieunkim singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT lijiangfei singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT wenchiyin singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT sabrinacoquenlorge singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT abilasharaobhatia singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT xiaoyunzhang singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT sammyshunwaishi singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT juheelee singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT noahahahn singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT wasirizvi singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT kyounghankim singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT hoonkisung singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT chichunghui singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT guojiguo singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches AT taeheekim singlecellandgeneticanalysesrevealconservedpopulationsandsignalingmechanismsofgastrointestinalstromalniches
_version_	1718383132977135616

Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches

Ejemplares similares