Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches
Wnt signals for intestinal stem cell self-renewal originate from the stroma and Paneth cells, but the source in stomach is unclear. Here the authors identify a conserved population of stromal cells adjacent to stomach epithelia where Gli2 activates Wnt ligands to promote gastrointestinal regeneratio...
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Auteurs principaux: | Ji-Eun Kim, Lijiang Fei, Wen-Chi Yin, Sabrina Coquenlorge, Abilasha Rao-Bhatia, Xiaoyun Zhang, Sammy Shun Wai Shi, Ju Hee Lee, Noah A. Hahn, Wasi Rizvi, Kyoung-Han Kim, Hoon-Ki Sung, Chi-chung Hui, Guoji Guo, Tae-Hee Kim |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
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Accès en ligne: | https://doaj.org/article/f2afc39b87d4469eb7631c0d62df5b58 |
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