A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits

Abstract The novel anti-VEGF drug conbercept has been used in the treatment of several retinal neovascular diseases. Owning to the alteration of the structure, the newest drug is capable of combining more molecular targets and present higher affinity to the angiogenesis promoting factors. However, i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jiaming Wang, Chunyan Lei, Lifei Tao, Quan Wu, Xiao Ke, Yiguo Qiu, Bo Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2b13e6082ec407ab433233c2773f883
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f2b13e6082ec407ab433233c2773f883
record_format	dspace
spelling	oai:doaj.org-article:f2b13e6082ec407ab433233c2773f8832021-12-02T12:32:56ZA safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits10.1038/s41598-017-00683-x2045-2322https://doaj.org/article/f2b13e6082ec407ab433233c2773f8832017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00683-xhttps://doaj.org/toc/2045-2322Abstract The novel anti-VEGF drug conbercept has been used in the treatment of several retinal neovascular diseases. Owning to the alteration of the structure, the newest drug is capable of combining more molecular targets and present higher affinity to the angiogenesis promoting factors. However, it is unknown whether it will cause any unwanted effects like other anti-VEGF agents. We studied the short-term safety of high concentration and high frequency intravitreal injection of conbercept in rabbits. Intraocular pressure, fundus-photography, ERGs were applied. Retinal morphology, the amount of apoptotic cells and protein levels of IL-6, IL-8 and TNF-α in the aqueous humor were determined. Retinal proteomics was detected using tandem mass tags (TMTs) quantitative mass spectrometry. The difference of IOP, ERGs, protein levels of inflammatory factors among rabbits received conbercept and PBS was not significant (P > 0.05). Fundus photographs and retinal morphology of animals in the conbercept-injected groups mimic those observed in the PBS-injected groups. No TUNEL-positive cell was seen in the retinal ganglion cell layer in the conbercept-injected groups. Proteomics did not show significant changes of inflammation or apoptosis associated proteins in the conbercept-injected eyes. We conclude that intravitreal injection of high concentration and high frequency conbercept is well tolerated at least in a short-term in rabbits.Jiaming WangChunyan LeiLifei TaoQuan WuXiao KeYiguo QiuBo LeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiaming Wang Chunyan Lei Lifei Tao Quan Wu Xiao Ke Yiguo Qiu Bo Lei A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
description	Abstract The novel anti-VEGF drug conbercept has been used in the treatment of several retinal neovascular diseases. Owning to the alteration of the structure, the newest drug is capable of combining more molecular targets and present higher affinity to the angiogenesis promoting factors. However, it is unknown whether it will cause any unwanted effects like other anti-VEGF agents. We studied the short-term safety of high concentration and high frequency intravitreal injection of conbercept in rabbits. Intraocular pressure, fundus-photography, ERGs were applied. Retinal morphology, the amount of apoptotic cells and protein levels of IL-6, IL-8 and TNF-α in the aqueous humor were determined. Retinal proteomics was detected using tandem mass tags (TMTs) quantitative mass spectrometry. The difference of IOP, ERGs, protein levels of inflammatory factors among rabbits received conbercept and PBS was not significant (P > 0.05). Fundus photographs and retinal morphology of animals in the conbercept-injected groups mimic those observed in the PBS-injected groups. No TUNEL-positive cell was seen in the retinal ganglion cell layer in the conbercept-injected groups. Proteomics did not show significant changes of inflammation or apoptosis associated proteins in the conbercept-injected eyes. We conclude that intravitreal injection of high concentration and high frequency conbercept is well tolerated at least in a short-term in rabbits.
format	article
author	Jiaming Wang Chunyan Lei Lifei Tao Quan Wu Xiao Ke Yiguo Qiu Bo Lei
author_facet	Jiaming Wang Chunyan Lei Lifei Tao Quan Wu Xiao Ke Yiguo Qiu Bo Lei
author_sort	Jiaming Wang
title	A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
title_short	A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
title_full	A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
title_fullStr	A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
title_full_unstemmed	A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
title_sort	safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f2b13e6082ec407ab433233c2773f883
work_keys_str_mv	AT jiamingwang asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT chunyanlei asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT lifeitao asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT quanwu asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT xiaoke asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT yiguoqiu asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT bolei asafetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT jiamingwang safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT chunyanlei safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT lifeitao safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT quanwu safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT xiaoke safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT yiguoqiu safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits AT bolei safetystudyofhighconcentrationandhighfrequencyintravitrealinjectionofconberceptinrabbits
_version_	1718393954898018304

A safety study of high concentration and high frequency intravitreal injection of conbercept in rabbits

Ejemplares similares