Burden of critically ill patients with influenza in a French catchment population

Abstract Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchm...

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Autores principales:	Romain Hernu, Marie Simon, Thomas Baudry, Jean-Sébastien Casalegno, Bruno Lina, Martin Cour, Laurent Argaud, the “Flu in Lyon ICUs” Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f2b3057446764ca09536ac13482470cd
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spelling	oai:doaj.org-article:f2b3057446764ca09536ac13482470cd2021-12-02T14:58:53ZBurden of critically ill patients with influenza in a French catchment population10.1038/s41598-021-89912-y2045-2322https://doaj.org/article/f2b3057446764ca09536ac13482470cd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89912-yhttps://doaj.org/toc/2045-2322Abstract Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04–1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza.Romain HernuMarie SimonThomas BaudryJean-Sébastien CasalegnoBruno LinaMartin CourLaurent Argaudthe “Flu in Lyon ICUs” Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Romain Hernu Marie Simon Thomas Baudry Jean-Sébastien Casalegno Bruno Lina Martin Cour Laurent Argaud the “Flu in Lyon ICUs” Study Group Burden of critically ill patients with influenza in a French catchment population
description	Abstract Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04–1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza.
format	article
author	Romain Hernu Marie Simon Thomas Baudry Jean-Sébastien Casalegno Bruno Lina Martin Cour Laurent Argaud the “Flu in Lyon ICUs” Study Group
author_facet	Romain Hernu Marie Simon Thomas Baudry Jean-Sébastien Casalegno Bruno Lina Martin Cour Laurent Argaud the “Flu in Lyon ICUs” Study Group
author_sort	Romain Hernu
title	Burden of critically ill patients with influenza in a French catchment population
title_short	Burden of critically ill patients with influenza in a French catchment population
title_full	Burden of critically ill patients with influenza in a French catchment population
title_fullStr	Burden of critically ill patients with influenza in a French catchment population
title_full_unstemmed	Burden of critically ill patients with influenza in a French catchment population
title_sort	burden of critically ill patients with influenza in a french catchment population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f2b3057446764ca09536ac13482470cd
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Burden of critically ill patients with influenza in a French catchment population

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